CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11775
Family Name Leucine-rich repeat serine/threonine-protein kinase 2 inhibitor [5-chloro-2-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone family
No. of Seeds 3 No. of Other Members 3
Family Centroid CFAMM00411783 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor 4 and Corticotropin-releasing factor receptor 1 Binder Superfamily
Class Class 3457

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
MK-6096 family 3 69
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
5-hydroxytryptamine receptor 4 ligand AGN-PC-00GB52 family 5 2
5-hydroxytryptamine receptor 4 ligand 2-(4-pyridin-4-ylpiperaz... 2 1
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 10 15
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 0
Glycogen synthase kinase-3 beta inhibitor CHEMBL1940990 family 3 3
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Transient receptor potential cation channel subfamily V member... 2 0
5-hydroxytryptamine receptor 4 ligand 4-amino-5-chloro-N-[1-[8... 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00411783 CHEMBL2178126 Bioactive [5-chloro-2-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone
CFAMM00411782 CHEMBL2178127 Bioactive [5-chloro-4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-methoxyphenyl]-morpholin-4-ylmethanone
CFAMM00411779 CHEMBL2178131 Bioactive [5-fluoro-2-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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