CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11776
Family Name Leucine-rich repeat serine/threonine-protein kinase 2 inhibitor 2-N-[2-chloro-4-(1-methyltetrazol-5-yl)phenyl]-4-N-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00411785 Functional Category Bioactive
Superfamily D(4) dopamine receptor Ligand L-745,870 Superfamily
Class Class 1567

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Aurora kinase A and Aurora kinase B inhibitor 3uol family 6 5
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Cyclin-dependent kinase 2 and MAP kinase-activated protein kin... 3 0
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
Cytochrome P450 3A4 and Cytochrome P450 2C8 inhibitor N-[3-[(1... 1 0
Activated CDC42 kinase 1 inhibitor AGN-PC-078WDN family 7 2
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00411785 CHEMBL2178136 Bioactive 2-N-[2-chloro-4-(1-methyltetrazol-5-yl)phenyl]-4-N-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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