CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11780
Family Name Beta-secretase 1 inhibitor 3-[5-[(4aR,7aR)-2-amino-3-methyl-4-oxo-6-pyridin-2-yl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile family
No. of Seeds 6 No. of Other Members 3
Family Centroid CFAMM00411789 Functional Category Bioactive
Superfamily Beta-secretase 1 and Neuropeptides B/W receptor type 1 Binder Superfamily
Class Class 3284

Cousin Family NamesSeedsMembers
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Beta-secretase 1 and Beta-secretase 2 inhibitor (5S)-2-amino-5... 3 39
Beta-secretase 1 and Beta-secretase 2 inhibitor (5S)-2-amino-5... 2 11
Beta-secretase 1 inhibitor (6S)-2-amino-6-[2-chloro-5-(5-prop-... 3 0
Smoothened homolog inhibitor 1,3-dioxo-2-[(1S,2R)-2-phenylcycl... 2 0
Beta-secretase 1 and Cathepsin D inhibitor 2'-amino-2,2,3'-tri... 1 1
Calcitonin gene-related peptide type 1 receptor ligand N-(1-me... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00411797 CHEMBL2178719 Bioactive 3-[5-[(4aR,7aR)-2-amino-6-(5-chloropyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile
CFAMM00411790 CHEMBL2178143 Bioactive 3-[5-[(4aR,7aR)-2-amino-3-methyl-6-(5-methylpyrimidin-2-yl)-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile
CFAMM00411796 CHEMBL2178718 Bioactive 3-[5-[(4aR,7aR)-2-amino-6-(5-fluoropyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile
CFAMM00411789 CHEMBL2178153 Bioactive 3-[5-[(4aR,7aR)-2-amino-3-methyl-4-oxo-6-pyridin-2-yl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile
CFAMM00411795 CHEMBL2178713 Bioactive 2-[(4aR,7aR)-2-amino-7a-[4-(3-cyanophenyl)thiophen-2-yl]-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-6-yl]pyridine-3-carbonitrile
CFAMM00411792 CHEMBL2178714 Bioactive 3-[5-[(4aR,7aR)-2-amino-6-(5-fluoropyridin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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