CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1179
Family Name Endothelin-1 receptor and Endothelin B receptor ligand (2R,3R,4S)-4-(1-benzofuran-6-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid family
No. of Seeds 3 No. of Other Members 2
Family Centroid CFAMM00320360 Functional Category Bioactive
Superfamily Endothelin-1 receptor and Endothelin B receptor Binder Superfamily 4
Class Class 579

Cousin Family NamesSeedsMembers
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
Histamine H3 receptor Ligand A-317920 Family 9 240
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 66
Histamine H3 receptor Ligand A-349821 Family 49 228
Melatonin receptor type 1A and Melatonin receptor type 1B Liga... 33 98
Peroxisome proliferator-activated receptor delta and Peroxisom... 20 8
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Endothelin-1 receptor and Endothelin B receptor ligand (2R,3R,... 5 4
Kappa-type opioid receptor ligand 2-(1-benzofuran-4-yl)-N-meth... 4 5
Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor liga... 12 0
Dipeptidyl peptidase 4 and Seprase inhibitor (2R)-2-[4-[[[(2S)... 17 19
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Kappa-type opioid receptor ligand N-[(1S)-2-[(3S)-3-hydroxypyr... 2 0
Arachidonate 5-lipoxygenase inhibitor methyl 5-[1-(2-butyl-1-b... 2 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00320360 CHEMBL112685 Bioactive (2R,3R,4S)-4-(1-benzofuran-6-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00320359 CHEMBL558148 Bioactive (2R,3R,4S)-4-(1-benzofuran-4-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00320361 CHEMBL112832 Bioactive (2R,3R,4S)-4-(1-benzofuran-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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