CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11810
Family Name Histone deacetylase 1 inhibitor 5-[5-[[(2-chlorophenyl)methylamino]methyl]pyridin-2-yl]-N-hydroxythiophene-2-carboxamide family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00411934 Functional Category Bioactive
Superfamily Mitogen-activated protein kinase 14 and Mitogen-activated protein kinase 11 Binder Superfamily
Class Class 718

Cousin Family NamesSeedsMembers
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Histone deacetylase 1 Inhibitor N-hydroxy-5-(pyridin-3-yl)thio... 9 46
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Dipeptidyl peptidase 1 inhibitor (2S)-2-amino-N-[(1S)-1-cyano-... 2 14
Neuropeptide S receptor and Prelamin-A/C ligand CHEMBL1367658 ... 1 7
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor lig... 2 8
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-073U... 3 8
Nuclear receptor ROR-gamma and Niemann-Pick C1 protein ligand ... 1 12
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 4
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QJ7P family 2 0
Neuromedin-K receptor ligand 3-methylsulfinyl-N-[(1S)-1-phenyl... 3 5
Metabotropic glutamate receptor 1 ligand AGN-PC-0A9TG5 family 11 10
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 4 10
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 2
Glycogen synthase kinase-3 beta inhibitor 7-(6-chloropyridin-2... 2 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Neuronal acetylcholine receptor subunit alpha-7 ligand AGN-PC-... 7 1
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 16
Coagulation factor X inhibitor AGN-PC-030DHH family 1 0
Cyclin-dependent kinase 8 and Cyclin-dependent kinase 5 inhibi... 1 6
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
Serine/threonine-protein kinase Chk1 inhibitor 2-(1H-indol-5-y... 2 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 6 5
Histone deacetylase 1 inhibitor N-hydroxy-5-[1-[2-[(1-methylin... 4 1
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 4 4
Metabotropic glutamate receptor 1 ligand SureCN8238697 family 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 4 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(benzen... 4 4
Intercellular adhesion molecule 1 and E-selectin inhibitor Sur... 1 0
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Epidermal growth factor receptor and Vascular endothelial grow... 14 19
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 1 4
Protein kinase C theta type and Tyrosine-protein kinase Fyn in... 4 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 2 0
High affinity nerve growth factor receptor ligand isothiazole,... 4 3
Intercellular adhesion molecule 1 and E-selectin inhibitor Sur... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00411933 CHEMBL385562 Bioactive N-hydroxy-5-[5-[[2-(1H-indol-3-yl)ethylamino]methyl]pyridin-2-yl]thiophene-2-carboxamide
CFAMM00411932 CHEMBL217881 Bioactive 5-[5-[[(4-chlorophenyl)methylamino]methyl]pyridin-2-yl]-N-hydroxythiophene-2-carboxamide
CFAMM00411931 CHEMBL387447 Bioactive 5-[5-[[2-(2-chlorophenyl)ethylamino]methyl]pyridin-2-yl]-N-hydroxythiophene-2-carboxamide
CFAMM00411934 CHEMBL386914 Bioactive 5-[5-[[(2-chlorophenyl)methylamino]methyl]pyridin-2-yl]-N-hydroxythiophene-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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