CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11849
Family Name Potassium voltage-gated channel subfamily H member 2 and 5-hydroxytryptamine receptor 4 ligand [4-[2-[4-[(2-methylpyrrolo[3,4-c]quinolin-4-yl)oxymethyl]piperidin-1-yl]ethyl]phenyl]methanol family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00324732 Functional Category Bioactive
Superfamily Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,3-c]quinoline Superfamily
Class Class 2208

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Phospholipase A2, membrane associated Inhibitor Varespladib Fa... 37 190
Arachidonate 5-lipoxygenase Inhibitor MK-591 Family 9 161
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
Apricoxib family 8 77
PF-02545920 family 16 140
Arachidonate 5-lipoxygenase-activating protein Inhibitor AM103... 14 12
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Lethal factor Inhibitor 3-(2,5-dimethyl-1h-pyrrol-1-yl)benzoic... 2 44
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Squalene synthase Inhibitor ER-119884 Family 2 3
Renin Inhibitor CP-305202 Family 9 30
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Peroxisome proliferator-activated receptor delta ligand SureCN... 8 19
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 11
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Arachidonate 5-lipoxygenase-activating protein inhibitor SureC... 5 0
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Thromboxane-A synthase and Thromboxane A2 receptor ligand Sure... 5 37
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Fatty-acid amide hydrolase 1 inhibitor methyl 6-[2-[3-(4-pheny... 8 5
Fatty-acid amide hydrolase 1 inhibitor [(2S)-6-phenoxy-1,2,3,4... 3 6
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
NS5B protein inhibitor AGN-PC-00A17Z family 1 23
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
Prostaglandin D2 receptor and Prostaglandin E2 receptor EP2 su... 2 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
NS5B protein inhibitor AC1O5AET family 3 1
Arachidonate 5-lipoxygenase-activating protein inhibitor SureC... 8 1
Cytochrome P450 3A4 and Cytochrome P450 2D6 inhibitor SureCN16... 8 4
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 10
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 4
Sphingosine 1-phosphate receptor 1 ligand 6-[2-[4-phenyl-3-(tr... 2 3
Cytosolic phospholipase A2 inhibitor AGN-PC-00BH8R family 6 13
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Peroxisome proliferator-activated receptor gamma and Peroxisom... 10 5
Prostaglandin E synthase inhibitor 3-[4-(3-cyanopropoxy)-3-met... 2 4
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
5-hydroxytryptamine receptor 4 and Potassium voltage-gated cha... 2 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 3
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 7 1
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 11 3
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 18 39
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 4 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Leukotriene A-4 hydrolase inhibitor SureCN3030546 family 9 1
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 2 6
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
Cysteinyl leukotriene receptor 1 ligand 2-[2-[5-[[3-[(E)-2-(6,... 1 8
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 1 4
Histamine H1 receptor and Histamine H2 receptor ligand SureCN6... 1 3
Histamine H1 receptor and Histamine H2 receptor ligand SureCN5... 3 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00412249 CHEMBL2179674 Bioactive 4-[2-[4-[(2-methylpyrrolo[3,4-c]quinolin-4-yl)oxymethyl]piperidin-1-yl]ethyl]benzoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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