CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11852
Family Name Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TSK inhibitor 3-[4-amino-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-propan-2-ylphenyl)benzamide family
No. of Seeds 4 No. of Other Members 0
Family Centroid CFAMM00412259 Functional Category Bioactive
Superfamily Angiopoietin-1 receptor and Vascular endothelial growth factor receptor 1 Binder Superfamily
Class Class 195

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Type-1 angiotensin II receptor Ligand Tasosartan Family 10 29
Prothrombin Inhibitor Dabigatran Family 7 182
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Interleukin-12 subunit alpha Inhibitor STA-5326 Family 2 51
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Gamma-aminobutyric acid A receptor Ligand Ocinaplon Family 1 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 37 10
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
Ibrutinib family 2 27
PHA848125 family 13 138
Smoothened homolog Inhibitor LY2940680 Family 3 18
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 4 32
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Aurora kinase B and Aurora kinase C Inhibitor PHA-680632 Family 5 72
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Metabotropic glutamate receptor 5 Ligand N-(1,3-diphenyl-1h-py... 6 37
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Prothrombin inhibitor 2-[(2S)-1-[(2R)-2-amino-3-phenylpropanoy... 3 16
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 1 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZYJE fa... 15 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Mitogen-activated protein kinase 14 inhibitor SureCN3632376 fa... 10 5
Mitogen-activated protein kinase 13 inhibitor N-cyclopropyl-3-... 16 40
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 18
Adenosine receptor A3 ligand AGN-PC-07N4XX family 6 10
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 5 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Orexin receptor type 1 and Orexin receptor type 2 ligand AGN-P... 2 24
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07RDWA fa... 1 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Poly [ADP-ribose] polymerase 1 inhibitor 2-[2-[4-(1H-indazol-3... 1 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1
Smoothened homolog inhibitor SureCN1091571 family 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Mitogen-activated protein kinase 14 inhibitor 3mvm family 6 1
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... 9 11
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M4U... 4 5
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M45... 8 1
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 19
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... 8 7
Mitogen-activated protein kinase 14 inhibitor AGN-PC-069K8I fa... 12 3
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3
Survival motor neuron protein inhibitor CHEMBL1583999 family 1 3
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 8 13
3-phosphoinositide-dependent protein kinase 1 and Rho-associat... 12 11
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
Aurora kinase A inhibitor AGN-PC-00EHLC family 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 34 4
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Prothrombin inhibitor AGN-PC-09QLAK family 10 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 1 4
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... 17 3
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
B1 bradykinin receptor ligand 6-(8-fluoro-4-methyl-1-oxophthal... 3 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 1
TGF-beta receptor type-1 ligand 3-[[3-(6-methylpyridin-2-yl)-4... 1 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 11 0
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 6 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 2 10
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
Hepatocyte growth factor receptor ligand 5-[(6-phenyl-[1,2,4]t... 6 2
Hepatocyte growth factor receptor ligand 5-[(6-thiophen-3-yl-[... 1 1
Hepatocyte growth factor receptor ligand 5-[[6-(3-hydroxypheny... 2 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-3-... 13 1
Mitogen-activated protein kinase 14 inhibitor ethyl N-[4-[5-(m... 5 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 10 0
Cell division cycle 7-related protein kinase and Casein kinase... 2 0
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Aurora kinase B and Aurora kinase A inhibitor (2S)-1-[4-[[1-[(... 12 4
Ribosomal protein S6 kinase beta-1 and RAC-alpha serine/threon... 4 0
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 6 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... 2 4
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 16 5
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Renin inhibitor AGN-PC-073MLF family 7 6
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 11 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
Tyrosine-protein kinase SYK and Potassium voltage-gated channe... 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 4 2
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
P2X purinoceptor 7 inhibitor SureCN109149 family 8 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Tyrosine-protein kinase ABL1 and Abelson tyrosine-protein kina... 3 0
Epithelial discoidin domain-containing receptor 1 and Mast/ste... 1 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Proto-oncogene tyrosine-protein kinase Src and Mast/stem cell ... 4 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 9 1
Casein kinase II subunit alpha inhibitor CHEMBL401945 family 12 1
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Mitogen-activated protein kinase 14 inhibitor ethyl 4-[5-[(3-f... 2 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 1
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 3 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 5
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 2
Type-1 angiotensin II receptor ligand 2-[(2-ethyl-5,7-dimethyl... 5 3
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 13
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 5 1
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 1 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Aurora kinase A and Aurora kinase B inhibitor N-[(3E)-3-[5-(mo... 3 2
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-04VNKY family 1 4
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Cannabinoid receptor 1 ligand AGN-PC-07R6O8 family 5 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07B2Q... 6 0
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07RBL... 5 0
Type-1 angiotensin II receptor ligand 2-[[(5-ethylpyrazolo[1,5... 1 0
MAP kinase-activated protein kinase 2 and Cyclin-dependent kin... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00412260 CHEMBL2179781 Bioactive 3-[4-amino-1-[(3R)-1-prop-2-ynoylpiperidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-propan-2-ylphenyl)benzamide
CFAMM00412259 CHEMBL2179804 Bioactive 3-[4-amino-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-propan-2-ylphenyl)benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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