CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11864
Family Name Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17i family
No. of Seeds 3 No. of Other Members 6
Family Centroid CFAMM00412318 Functional Category Bioactive
Superfamily Cathepsin K and Melatonin receptor type 1B Binder Superfamily
Class Class 666

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Avanafi... 3 16
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 1 ligand AGN-PC-03I5TW family 3 12
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 7
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Cathepsin K and Cathepsin L1 inhibitor 2-Cyano-pyrimidine, 17a... 5 8
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 4 2
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 11 1
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 2 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Orexin receptor type 1 and Orexin receptor type 2 ligand SureC... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00412318 CHEMBL384685 Bioactive 2-Cyano-pyrimidine, 17i
CFAMM00412324 CHEMBL436303 Bioactive 2-Cyano-pyrimidine, 17j
CFAMM00412317 CHEMBL218007 Bioactive 2-Cyano-pyrimidine, 17h

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27058 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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