| Cousin Family Names | Seeds | Members |
|---|
| Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... | 5 | 644 |
| Benzodiazepine receptor Ligand Midazolam Family | 5 | 160 |
| Omega 1 Benzodiazepine receptor Ligand Zaleplon Family | 6 | 589 |
| Toll-like receptor 7 Ligand Imiquimod Family | 3 | 237 |
| Histamine H1 receptor Ligand Mizolastine Family | 14 | 603 |
| Metabotropic glutamate receptor 5 Ligand ADX-48621 Family | 15 | 444 |
| C-X-C chemokine receptor type 4 Ligand AMD-070 Family | 12 | 800 |
| Transient receptor potential cation channel subfamily V member... | 16 | 295 |
| Transient receptor potential cation channel subfamily V member... | 15 | 457 |
| Vascular endothelial growth factor Inhibitor PTC299 Family | 6 | 145 |
| Cyclin-dependent kinase 2 Inhibitor Seliciclib Family | 29 | 292 |
| Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... | 10 | 56 |
| Fibroblast growth factor receptor 2 and Fibroblast growth fact... | 11 | 86 |
| Cannabinoid receptor 1 Ligand CP-945598 Family | 18 | 173 |
| C-reactive protein Inhibitor ISIS-CRP Family | 4 | 105 |
| Translocator protein Inhibitor Emapunil Family | 7 | 89 |
| 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... | 14 | 234 |
| HCV NS4B protein Inhibitor Clemizole Family | 2 | 43 |
| Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... | 13 | 55 |
| RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... | 35 | 69 |
| Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family | 9 | 29 |
| Corticotropin-releasing factor receptor 1 Ligand Dmp-695/696 F... | 11 | 20 |
| D(4) dopamine receptor Ligand L-745,870 Family | 30 | 205 |
| Glucan synthesis regulatory protein Inhibitor Pyridobenzimidaz... | 2 | 12 |
| Corticotropin-releasing factor receptor 1 Ligand R121919 Family | 26 | 84 |
| Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family | 3 | 33 |
| Histamine H3 receptor Ligand SCH79687 Family | 11 | 29 |
| Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... | 13 | 14 |
| Adenosine receptor A3 Ligand 2,6-bis(4-chlorophenyl)-9h-purine... | 4 | 12 |
| Farnesyltransferase beta subunit, putative and Protein farnesy... | 20 | 81 |
| Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... | 18 | 109 |
| Epidermal growth factor receptor Ligand PD-158780 Family | 98 | 89 |
| Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... | 3 | 16 |
| Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... | 6 | 5 |
| Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... | 19 | 165 |
| Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family | 14 | 103 |
| Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... | 7 | 12 |
| Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... | 8 | 5 |
| RAC-gamma serine/threonine-protein kinase and Rho-associated p... | 16 | 46 |
| Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... | 7 | 51 |
| Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... | 41 | 59 |
| Mitogen-activated protein kinase kinase kinase 8 and Stromelys... | 6 | 53 |
| Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family | 4 | 1 |
| Histamine H4 receptor Ligand A-943931 Family | 14 | 11 |
| RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... | 219 | 124 |
| Potassium voltage-gated channel subfamily H member 2 Ligand AZ... | 21 | 42 |
| Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family | 5 | 6 |
| Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... | 17 | 59 |
| Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... | 3 | 0 |
| Type-2 angiotensin II receptor Ligand L-158282 Family | 24 | 58 |
| Type-2 angiotensin II receptor Ligand L-158809 Family | 22 | 136 |
| Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... | 3 | 10 |
| Sodium channel protein type 1 subunit alpha and Sodium channel... | 10 | 14 |
| Protein farnesyltransferase subunit beta Inhibitor BMS-316810 ... | 11 | 18 |
| Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... | 3 | 63 |
| Metabotropic glutamate receptor 5 Ligand 2-(3,5-dichlorophenyl... | 2 | 3 |
| Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... | 3 | 13 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 4 | 2 |
| Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... | 7 | 7 |
| Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YT9... | 28 | 20 |
| Platelet-activating factor receptor ligand SureCN9523843 family | 4 | 4 |
| Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... | 6 | 60 |
| Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... | 3 | 0 |
| Mitogen-activated protein kinase 14 and Mitogen-activated prot... | 2 | 21 |
| Platelet-activating factor receptor ligand AGN-PC-0750SP family | 4 | 0 |
| Platelet-activating factor receptor ligand SureCN9383514 family | 4 | 1 |
| RAF proto-oncogene serine/threonine-protein kinase and Serine/... | 3 | 5 |
| 5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... | 7 | 4 |
| Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... | 8 | 8 |
| Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... | 16 | 5 |
| Aurora kinase A and Aurora kinase B inhibitor 3uol family | 6 | 5 |
| Melanin-concentrating hormone receptor 1 and Potassium voltage... | 8 | 27 |
| Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... | 7 | 10 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 4 | 27 |
| Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... | 1 | 0 |
| Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... | 4 | 19 |
| Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... | 3 | 11 |
| Cellular tumor antigen p53 inhibitor CHEMBL1318500 family | 1 | 0 |
| Type-1B angiotensin II receptor ligand SureCN683399 family | 3 | 0 |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 s... | 4 | 0 |
| D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... | 13 | 8 |
| Dihydrofolate reductase and Bifunctional dihydrofolate reducta... | 5 | 0 |
| Prelamin-A/C inhibitor CHEMBL1472945 family | 1 | 32 |
| Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... | 3 | 10 |
| Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... | 2 | 1 |
| Survival motor neuron protein and Nuclear receptor ROR-gamma l... | 1 | 2 |
| Nuclear receptor ROR-gamma and Mitogen-activated protein kinas... | 1 | 10 |
| Growth hormone secretagogue receptor type 1 and Dihydrofolate ... | 3 | 6 |
| Coagulation factor X and Trypsin-1 inhibitor 1-(3-carbamimidoy... | 4 | 1 |
| Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... | 5 | 0 |
| Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... | 3 | 7 |
| Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family | 1 | 3 |
| Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... | 6 | 14 |
| Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... | 9 | 6 |
| Signal transducer and activator of transcription 6 inhibitor A... | 3 | 0 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 2 | 1 |
| Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... | 4 | 0 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 3 | 5 |
| Nociceptin receptor and Potassium voltage-gated channel subfam... | 10 | 1 |
| Corticotropin-releasing factor receptor 1 ligand 5-(2,4-dichlo... | 5 | 17 |
| Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... | 2 | 4 |
| Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... | 2 | 2 |
| Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... | 4 | 14 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 3 | 11 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 2 | 0 |
| Sodium-dependent serotonin transporter and 5-hydroxytryptamine... | 5 | 8 |
| Vasopressin V1a receptor and Vasopressin V2 receptor ligand 8-... | 6 | 2 |
| Dipeptidyl peptidase 4 inhibitor Aminomethylpyrimidine 1ck family | 6 | 3 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 1 | 8 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 15 | 3 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 2 | 0 |
| Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... | 4 | 0 |
| Aurora kinase A and Aurora kinase B inhibitor 2-[[5-chloro-2-[... | 3 | 7 |
| Aurora kinase B and Vascular endothelial growth factor recepto... | 1 | 2 |
| Epidermal growth factor receptor and Receptor tyrosine-protein... | 8 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... | 3 | 0 |
| Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... | 4 | 5 |
| Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 2-[8-... | 2 | 5 |
| D(4) dopamine receptor and Alpha-1D adrenergic receptor ligand... | 3 | 3 |
| Transient receptor potential cation channel subfamily V member... | 4 | 0 |
| D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... | 2 | 0 |
| High affinity nerve growth factor receptor ligand N-[3-amino-5... | 4 | 10 |
| Serine/threonine-protein kinase SMG1 and Serine/threonine-prot... | 10 | 0 |
| Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... | 3 | 1 |
| Smoothened homolog inhibitor N-[4-chloro-3-(5-phenyl-1H-imidaz... | 4 | 1 |
| Urokinase plasminogen activator surface receptor ligand 3-(1H-... | 4 | 0 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 7 | 4 |
| Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... | 2 | 0 |
| CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... | 1 | 4 |
| P2X purinoceptor 7 inhibitor SureCN109432 family | 10 | 28 |
| Corticotropin-releasing factor receptor 1 and Corticotropin-re... | 2 | 1 |
| Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... | 3 | 1 |
| Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... | 6 | 5 |
| Corticotropin-releasing factor receptor 1 and Corticotropin-re... | 6 | 3 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... | 5 | 1 |
| Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... | 2 | 1 |
| Corticotropin-releasing factor receptor 1 and Corticotropin-re... | 5 | 2 |
| Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand pheny... | 1 | 0 |
| Cathepsin K inhibitor SureCN4141224 family | 3 | 0 |
| Cathepsin K and Cathepsin S inhibitor SureCN4138353 family | 3 | 0 |
| Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... | 2 | 1 |
| Nociceptin receptor and Potassium voltage-gated channel subfam... | 5 | 2 |
| Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... | 1 | 0 |
| Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... | 4 | 1 |
| Corticotropin-releasing factor receptor 1 ligand SureCN7215846... | 4 | 1 |
| Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... | 4 | 3 |
| Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... | 1 | 0 |
| Tyrosine-protein kinase Lck inhibitor AGN-PC-03IU3J family | 2 | 0 |
| Type-1 angiotensin II receptor ligand SureCN7390271 family | 2 | 1 |
| Adenosine kinase inhibitor SureCN8248615 family | 2 | 3 |
| Coagulation factor X inhibitor SureCN1652469 family | 2 | 1 |
| Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... | 1 | 3 |
| Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... | 2 | 1 |
| Adenosine receptor A1 ligand 3-[(2-chlorophenyl)methyl]-N-cycl... | 1 | 1 |
| Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... | 1 | 0 |
| 5-hydroxytryptamine receptor 6 ligand 8-(1-pyrrolidin-3-ylpyrr... | 1 | 0 |
| Serine/threonine-protein kinase B-raf inhibitor 1-[2-[[4-[2-cy... | 2 | 0 |
| Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-a]pyridine der... | 4 | 0 |
| Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... | 3 | 4 |
| Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... | 3 | 0 |
| Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... | 1 | 0 |
| Nuclear receptor subfamily 1 group I member 2 ligand AGN-PC-07... | 2 | 13 |
| Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... | 2 | 3 |
| Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... | 7 | 0 |
| Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... | 2 | 0 |
| Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... | 4 | 0 |
| Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... | 9 | 0 |
| Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3-[2-... | 9 | 0 |
| Gonadotropin-releasing hormone receptor ligand AGN-PC-00AWCA f... | 1 | 0 |
| Carbonic anhydrase 2 and Carbonic anhydrase 9 inhibitor ZINC00... | 1 | 0 |
| 5-hydroxytryptamine receptor 2B ligand SureCN1299053 family | 1 | 1 |
| Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... | 1 | 0 |
| Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... | 14 | 0 |
| Cannabinoid receptor 1 ligand AGN-PC-07CPJ5 family | 9 | 14 |
| Neuropeptide Y receptor type 5 ligand AGN-PC-01NS1A family | 7 | 0 |
| Histamine H4 receptor ligand 2-[[6-chloro-2-(4-methylpiperazin... | 7 | 2 |
| Dihydrofolate reductase inhibitor 5-[(7-chloro-10-methylsulfan... | 1 | 0 |
| D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... | 1 | 2 |
| Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... | 2 | 0 |
| Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... | 1 | 5 |
Statistics of CFAM Database |
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
|
How to cite our database |
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C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
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Last update by |
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2014.08.29
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