CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11866
Family Name Cathepsin K and Cathepsin L1 inhibitor 2-Cyano-pyrimidine, 17a family
No. of Seeds 5 No. of Other Members 8
Family Centroid CFAMM00412342 Functional Category Bioactive
Superfamily Cathepsin K and Melatonin receptor type 1B Binder Superfamily
Class Class 666

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Histamine H1 receptor Ligand Mepyramine Family 5 65
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 5 12
SB1518 family 7 103
JAK Inhibitor Momelotinib Family 33 83
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 2 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2J2 inhib... 1 7
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 8
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Proto-oncogene tyrosine-protein kinase Src and Epidermal growt... 9 9
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17i ... 3 6
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Ephrin type-A receptor 3 and Tyrosine-protein kinase Fgr ligan... 1 3
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
Dihydrofolate reductase and Dihydrofolate reductase type 1 inh... 8 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 12
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 21
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 3
Cathepsin S and Cathepsin L1 inhibitor AGN-PC-077QOL family 1 1
Cathepsin S and Cathepsin L1 inhibitor AGN-PC-077QDL family 5 0
P2X purinoceptor 3 and P2X purinoceptor 2 inhibitor 2-[[4-amin... 10 9
Acyl-CoA desaturase inhibitor SureCN1182546 family 2 5
Signal transducer and activator of transcription 6 inhibitor A... 4 0
Signal transducer and activator of transcription 6 inhibitor 2... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00412333 CHEMBL218024 Bioactive 2-Cyano-pyrimidine, 16b
CFAMM00412339 CHEMBL449096 Bioactive 2-Cyano-pyrimidine, 17g
CFAMM00412338 CHEMBL221707 Bioactive 2-Cyano-pyrimidine, 17b
CFAMM00412342 CHEMBL220496 Bioactive 2-Cyano-pyrimidine, 17a
CFAMM00412340 CHEMBL385632 Bioactive 2-Cyano-pyrimidine, 16c

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27518 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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