CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11875
Family Name cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A inhibitor 2-(6-chloropyridin-3-yl)-N-(1-methylpyrazol-4-yl)-4-propan-2-yloxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00412386 Functional Category Bioactive
Superfamily Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Binder Superfamily
Class Class 481

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Reverse transcriptase/RNaseH inhibitor AC1LALKM family 2 19
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 18 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 1
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00412387 CHEMBL2204539 Bioactive 2-(6-chloropyridin-3-yl)-N-methyl-4-propan-2-yloxy-N-(1H-pyrazol-4-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
CFAMM00412386 CHEMBL2180421 Bioactive 2-(6-chloropyridin-3-yl)-N-(1-methylpyrazol-4-yl)-4-propan-2-yloxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
CFAMM00412385 CHEMBL2204537 Bioactive [2-(6-chloropyridin-3-yl)-4-propan-2-yloxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-(1-methylimidazol-4-yl)methanone;hydrochloride

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27511 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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