CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11881
Family Name cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A inhibitor N-[(3R)-1,1-dioxothiolan-3-yl]-2-[(E)-2-[3-methyl-7-(trifluoromethyl)quinoxalin-2-yl]ethenyl]-6-pyrrolidin-1-ylpyrimidin-4-amine family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00412401 Functional Category Bioactive
Superfamily Growth hormone secretagogue receptor type 1 and cAMP Binder Superfamily
Class Class 857

Cousin Family NamesSeedsMembers
GDC-0349 family 44 77
Tryptase Inhibitor Babim Family 12 90
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Serine/threonine-protein kinase ATR and Serine/threonine-prote... 8 10
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Mitogen-activated protein kinase 14 inhibitor 6-[2-[2-chloro-6... 2 0
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 1 0


External ID

Functional Category

Molecule Name

CFAMM00412401 CHEMBL2180441 Bioactive N-[(3R)-1,1-dioxothiolan-3-yl]-2-[(E)-2-[3-methyl-7-(trifluoromethyl)quinoxalin-2-yl]ethenyl]-6-pyrrolidin-1-ylpyrimidin-4-amine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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