CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11884
Family Name Vascular endothelial growth factor receptor 2 and Platelet-derived growth factor receptor beta ligand N-[3-[2-(cyclopropanecarbonylamino)imidazo[1,2-b]pyridazin-6-yl]oxyphenyl]-2,5-dimethylpyrazole-3-carboxamide family
No. of Seeds 16 No. of Other Members 11
Family Centroid CFAMM00152263 Functional Category Bioactive
Superfamily Corticotropin-releasing factor receptor 1 Ligand GW876008 Superfamily
Class Class 1070

Cousin Family NamesSeedsMembers
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
MK-6096 family 3 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand CGS-15... 24 47
Mitogen-activated protein kinase 14 Inhibitor CP-808844 Family 39 43
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Adenosine receptor A2a ligand SureCN6867940 family 13 13
DNA-(apurinic or apyrimidinic site) lyase and Nuclear receptor... 2 10
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 8 0
Neuropeptide Y receptor type 5 ligand SureCN5771669 family 2 3
Adenosine receptor A3 and Adenosine receptor A2b ligand CHEMBL... 5 0
Survival motor neuron protein and Neuropeptide S receptor liga... 1 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 5 8
Adenosine receptor A2a ligand 5-[[[(2R)-1-[(2-chloropyridin-4-... 5 0
Adenosine receptor A2a ligand 2-(furan-2-yl)-7-[3-[(4-phenylpi... 11 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 5
Adenosine receptor A3 ligand CHEMBL1834703 family 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 3
Metabotropic glutamate receptor 5 ligand SureCN4297614 family 2 5
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 1 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
Adenosine receptor A3 ligand CHEMBL211055 family 3 0
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 6
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 0
Adenosine receptor A2a and Adenosine receptor A1 ligand 5-[(7S... 6 1
Adenosine receptor A2a ligand 5-[(7S,9aS)-7-[(2-fluorophenoxy)... 5 4
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 12 3
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 0
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Vascular endothelial growth factor receptor 2 and Platelet-der... 3 0
Adenosine receptor A2a ligand 3-[(2-bromophenyl)methyl]-8-(fur... 2 0
Adenosine receptor A2a ligand 8-(furan-2-yl)-3-[2-[4-(1,3-thia... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 25 5
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 29 1
Hepatocyte growth factor receptor ligand AGN-PC-00AG7Q family 1 10
Adenosine receptor A2a and Adenosine receptor A1 ligand 1-[(2-... 2 0
Adenosine receptor A2b and Adenosine receptor A1 ligand N-(1,3... 2 7
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Adenosine receptor A3 and Adenosine receptor A2a ligand (3R,4S... 1 0
Adenosine receptor A2a ligand SureCN8368237 family 1 0
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 2 2
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Aurora kinase B and Aurora kinase A inhibitor N-(furan-2-ylmet... 2 1
Vascular endothelial growth factor receptor 2 and Vascular end... 2 8
Vascular endothelial growth factor receptor 2 and Vascular end... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00412427 CHEMBL2348995 Bioactive N-[3-[2-(cyclopropanecarbonylamino)imidazo[1,2-b]pyridazin-6-yl]oxyphenyl]-5-methyl-2-phenylpyrazole-3-carboxamide
CFAMM00412413 CHEMBL2349012 Bioactive N-[3-[2-(cyclopropanecarbonylamino)imidazo[1,2-b]pyridazin-6-yl]oxyphenyl]-2-methyl-5-(trifluoromethyl)pyrazole-3-carboxamide
CFAMM00412432 CHEMBL2348992 Bioactive N-[5-[2-(cyclopropanecarbonylamino)imidazo[1,2-b]pyridazin-6-yl]oxy-2-ethylphenyl]-2,5-dimethylpyrazole-3-carboxamide
CFAMM00412425 CHEMBL2348998 Bioactive N-[3-[2-(cyclopropanecarbonylamino)imidazo[1,2-b]pyridazin-6-yl]oxyphenyl]-1,5-dimethylpyrazole-3-carboxamide
CFAMM00412431 CHEMBL2348993 Bioactive N-[3-[2-(cyclopropanecarbonylamino)imidazo[1,2-b]pyridazin-6-yl]oxy-2-methylphenyl]-2,5-dimethylpyrazole-3-carboxamide
CFAMM00412411 CHEMBL2349000 Bioactive N-[3-[2-(cyclopropanecarbonylamino)imidazo[1,2-b]pyridazin-6-yl]oxyphenyl]-3-methyl-1,2-oxazole-5-carboxamide
CFAMM00412424 CHEMBL2348999 Bioactive N-[3-[2-(cyclopropanecarbonylamino)imidazo[1,2-b]pyridazin-6-yl]oxyphenyl]-3-methyltriazole-4-carboxamide
CFAMM00412430 CHEMBL2348990 Bioactive N-[2-chloro-5-[2-(cyclopropanecarbonylamino)imidazo[1,2-b]pyridazin-6-yl]oxyphenyl]-2,5-dimethylpyrazole-3-carboxamide
CFAMM00412423 CHEMBL2349001 Bioactive N-[3-[2-(cyclopropanecarbonylamino)imidazo[1,2-b]pyridazin-6-yl]oxyphenyl]-1,2-oxazole-5-carboxamide
CFAMM00412429 CHEMBL2348991 Bioactive N-[5-[2-(cyclopropanecarbonylamino)imidazo[1,2-b]pyridazin-6-yl]oxy-2-fluorophenyl]-2,5-dimethylpyrazole-3-carboxamide
CFAMM00412428 CHEMBL2348994 Bioactive N-[3-[2-(cyclopropanecarbonylamino)imidazo[1,2-b]pyridazin-6-yl]oxy-4-methylphenyl]-2,5-dimethylpyrazole-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45592 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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