CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11889
Family Name cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A inhibitor 1-pyridin-4-yl-3-(2-quinolin-4-ylpyrazol-3-yl)pyridazin-4-one family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00412439 Functional Category Bioactive
Superfamily cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Binder Superfamily 6
Class Class 1032

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Interleukin-1 beta and Interleukin-6 Inhibitor Ibudilast Family 2 11
D(4) dopamine receptor Ligand SPI-376 Family 7 84
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 4
Cannabinoid receptor 2 Ligand JWH-249 Family 7 13
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 2
Hepatocyte growth factor receptor ligand 9-[[3-methoxypropyl(m... 17 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R6UP family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00412440 CHEMBL2180794 Bioactive 3-[2-(3-chlorophenyl)pyrazol-3-yl]-1-quinolin-6-ylpyridazin-4-one
CFAMM00412439 CHEMBL2180792 Bioactive 1-pyridin-4-yl-3-(2-quinolin-4-ylpyrazol-3-yl)pyridazin-4-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27520 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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