CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1189
Family Name Integrin beta-3 and Integrin alpha-V inhibitor 2-[1-[2-[[4-(1H-benzimidazol-2-ylamino)cyclohexyl]methylamino]-2-oxoethyl]-2-oxo-4,5-dihydro-3H-1-benzazepin-5-yl]acetic acid family
No. of Seeds 6 No. of Other Members 2
Family Centroid CFAMM00320428 Functional Category Bioactive
Superfamily Pol polyprotein and Integrin beta-3 Binder Superfamily
Class Class 716

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Type-1 angiotensin II receptor Ligand Telmisartan Family 4 181
Renin Inhibitor Remikiren Family 100 126
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Histamine H1 receptor Ligand Mizolastine Family 14 603
Prothrombin Inhibitor Dabigatran Family 7 182
BIBT986 family 7 96
Eluxadoline family 4 85
Tryptase Inhibitor Babim Family 12 90
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 50 17
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Type-2 angiotensin II receptor Ligand PD-123319 Family 3 39
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Pol polyprotein inhibitor AC1LAQE0 family 13 4
Pol polyprotein inhibitor Hydroxyethylene deriv. 12 family 13 10
Pol polyprotein inhibitor (2S)-4-(1H-benzimidazol-2-ylmethyl)-... 1 0
Caspase-1 inhibitor (3S)-3-[[(2S)-4-[2-(5-methylbenzimidazol-1... 5 27
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Integrin alpha-4 inhibitor AC1O7HJM family 3 0
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 2 9
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Type-2 angiotensin II receptor ligand (6S)-5-(2,2-diphenylacet... 1 0
Delta-type opioid receptor ligand ethyl N-[3-[(R)-[4-[ethyl(me... 2 6
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
C-C chemokine receptor type 5 ligand AC1MHRXO family 5 1
Integrin beta-1 and Integrin alpha-4 inhibitor (5R)-5-[[(2R)-2... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Integrin beta-3 and Integrin alpha-V inhibitor 2-[1-[2-[[4-(1H... 2 8
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Renin inhibitor (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohe... 6 0
Putative Bioactive N-[(2R)-2-[(2S)-2-(1H-benzimidazol-2-yl)pyr... 2 0
Melanin-concentrating hormone receptor 1 ligand SureCN3832854 ... 3 2
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00320431 CHEMBL258325 Bioactive 2-[1-[2-[[4-(1H-benzimidazol-2-ylamino)cyclohexyl]methylamino]-2-oxoethyl]-2-oxoquinolin-4-yl]acetic acid
CFAMM00320428 CHEMBL269950 Bioactive 2-[1-[2-[[4-(1H-benzimidazol-2-ylamino)cyclohexyl]methylamino]-2-oxoethyl]-2-oxo-4,5-dihydro-3H-1-benzazepin-5-yl]acetic acid
CFAMM00320427 CHEMBL344162 Bioactive AGN-PC-00FJLT
CFAMM00320426 CHEMBL113063 Bioactive SureCN6300515
CFAMM00320432 CHEMBL255952 Bioactive 2-[1-[2-[[4-(1H-benzimidazol-2-ylamino)cyclohexyl]methylamino]-2-oxoethyl]-2-oxo-3,4-dihydroquinolin-4-yl]acetic acid
CFAMM00320425 CHEMBL404371 Bioactive 2-[1-[2-[[4-(1H-benzimidazol-2-ylamino)phenyl]methylamino]-2-oxoethyl]-2-oxo-4,5-dihydro-3H-1-benzazepin-5-yl]acetic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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