CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1190
Family Name Muscarinic acetylcholine receptor M2 ligand [4-[(3R)-3-methyl-4-[(1S)-1-[4-(3-methylphenyl)sulfonylphenyl]ethyl]piperazin-1-yl]piperidin-1-yl]-(2-methylphenyl)methanone family
No. of Seeds 3 No. of Other Members 4
Family Centroid CFAMM00320440 Functional Category Bioactive
Superfamily Acetylcholinesterase and Butyrylcholinesterase Binder Superfamily
Class Class 2586

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
C-C chemokine receptor type 5 Ligand AZD5672 Family 25 70
Substance-P receptor Ligand Orvepitant Family 11 46
Bavisant family 9 65
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Carbonic anhydrase 2 Inhibitor N-benzyl-4-sulfamoyl-benzamide ... 12 44
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Muscarinic acetylcholine receptor M2 Ligand SCH-211803 Family 3 6
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
C-C chemokine receptor type 5 ligand AC1NUIO8 family 12 11
C-C chemokine receptor type 5 ligand AC1L9USC family 3 2
Kappa-type opioid receptor ligand 6-[2-oxo-2-[(2S)-2-(pyrrolid... 6 4
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745OU family 6 6
Acetylcholinesterase and Butyrylcholinesterase inhibitor N-[2-... 3 7
Acetylcholinesterase inhibitor 5-benzoyl-2-[2-(1-benzylpiperid... 2 3
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 2 5
C-C chemokine receptor type 5 ligand AGN-PC-075XOD family 2 0
Cannabinoid receptor 2 ligand AGN-PC-04VLWN family 9 4
Cannabinoid receptor 2 ligand N-cyclohexyl-4-propan-2-yl-3-pyr... 2 2
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 4 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
C-C chemokine receptor type 5 ligand N-[1-[(3R)-4-[benzenesulf... 3 1
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[ethyl-[2-(4... 1 1
Cannabinoid receptor 1 ligand 1-[4-[3-cyclopropyl-5-(trifluoro... 4 1
C-C chemokine receptor type 5 ligand N-benzyl-N-[(3R)-1-[(1S,5... 1 3
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2J2 inhib... 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00320433 CHEMBL354461 Bioactive (2-methylphenyl)-[4-[(3R)-3-methyl-4-[(1S)-1-[4-[3-(trifluoromethyl)phenyl]sulfonylphenyl]ethyl]piperazin-1-yl]piperidin-1-yl]methanone
CFAMM00320440 CHEMBL165035 Bioactive [4-[(3R)-3-methyl-4-[(1S)-1-[4-(3-methylphenyl)sulfonylphenyl]ethyl]piperazin-1-yl]piperidin-1-yl]-(2-methylphenyl)methanone
CFAMM00320438 CHEMBL113072 Bioactive (2S)-Piperazine, 4-[1-(2,6-dimethylbenzoyl)-4-methyl-4-piperidinyl]-2-methyl-1-[(1S)-1-[4-(methylsulfonyl)phenyl]ethyl]-

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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