CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11900
Family Name 5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine receptor 7 ligand 4-iodo-6-[(1-propylpiperidin-4-yl)methoxy]phenanthridine family
No. of Seeds 4 No. of Other Members 4
Family Centroid CFAMM00412233 Functional Category Bioactive
Superfamily Squalene synthase Inhibitor ER-119884 Superfamily
Class Class 1076

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Multidrug resistance protein 3 Inhibitor LY335979 Family 1 3
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
Apricoxib family 8 77
Grt 6005/06 family 4 22
PF-02545920 family 16 140
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Melanin-concentrating hormone receptor 1 Ligand 8-sec-butoxy-q... 30 39
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Metabotropic glutamate receptor 1 Ligand JNJ-16259685 Family 3 20
Squalene synthase Inhibitor ER-119884 Family 2 3
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 18
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YQD... 1 5
Neuropeptide Y receptor type 1 ligand SureCN7959923 family 1 6
5-hydroxytryptamine receptor 2A and Alpha-1A adrenergic recept... 4 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Bloom syndrome protein and Prelamin-A/C inhibitor Dubinidine f... 1 17
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Leukotriene B4 receptor 1 ligand SureCN8987110 family 8 20
Leukotriene B4 receptor 1 ligand SureCN8987047 family 4 3
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Coagulation factor X and Anionic trypsin-2 inhibitor AGN-PC-07... 1 1
D(2) dopamine receptor ligand 129722-25-4 family 2 2
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Coagulation factor X and Prothrombin inhibitor AGN-PC-0759SH f... 5 4
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
Hepatocyte growth factor receptor ligand AGN-PC-08XYVH family 1 1
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Cannabinoid receptor 1 ligand SureCN5355779 family 16 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Muscarinic acetylcholine receptor M3 ligand 3-fluoro-2-(3-pipe... 3 1
Cysteinyl leukotriene receptor 1 ligand SureCN7008285 family 12 97
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
Histamine H3 receptor and D(3) dopamine receptor ligand BODILI... 1 0
Substance-P receptor and Sodium-dependent serotonin transporte... 11 6
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Corticotropin-releasing factor receptor 1 ligand 3-ethyl-1-(2-... 5 15
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[4... 7 4
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... 4 4
C5a anaphylatoxin chemotactic receptor 1 ligand 2-(2,6-diethyl... 3 5
Renin inhibitor SureCN6043852 family 2 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 10
D(2) dopamine receptor ligand SureCN10575660 family 1 1
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Prothrombin and Trypsin-1 inhibitor AGN-PC-074I4I family 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PJ... 4 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Protein kinase C theta type and Protein kinase C delta type in... 10 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 18 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 18 0
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R,... 2 0
Dipeptidyl peptidase 4 inhibitor 2-[3-(aminomethyl)-4-(4-fluor... 3 0
Acetylcholinesterase inhibitor 2-methoxy-6-[5-(6-methoxy-1-met... 2 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 4
Small conductance calcium-activated potassium channel protein ... 1 1
Histidine-rich protein PFHRP-II inhibitor AGN-PC-075SYG family 1 0
Gonadotropin-releasing hormone receptor ligand 3-(3,5-dimethyl... 1 3
Beta-lactamase and Muscleblind-like protein 1 inhibitor 2,3-Bi... 1 2
Metabotropic glutamate receptor 1 ligand (Z)-[(3-ethyl-2-metho... 1 4
2,4,6-trimethyl-2,3-dihydrofuro[3,2-c]quinoline NP ZINC0009476... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00412503 CHEMBL2181188 Bioactive 4-chloro-6-[(1-propylpiperidin-4-yl)methoxy]phenanthridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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