CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11918
Family Name Beta-secretase 1 and Cytochrome P450 3A4 inhibitor N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-(3-pyridin-4-ylphenyl)butan-2-yl]-2-methoxyacetamide family
No. of Seeds 3 No. of Other Members 7
Family Centroid CFAMM00402179 Functional Category Bioactive
Superfamily Beta-secretase 1 and Cathepsin D Binder Superfamily 4
Class Class 284

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Indinavir Family 36 211
Cyclooxygenase Inhibitor Oxaprozin Family 33 450
Pristinamycin family 2 2
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Plasmepsin-2 Inhibitor KNI-10526 Family 8 10
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-[5-(4-hydroxyphe... 4 36
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Histone deacetylase 1 and Histone deacetylase 2 inhibitor AGN-... 4 15
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Thromboxane-A synthase and Thromboxane A2 receptor ligand Sure... 5 37
Fatty-acid amide hydrolase 1 inhibitor methyl 6-[2-[3-(4-pheny... 8 5
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 4 4
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-4-[[(4S)... 34 23
Beta-secretase 1 inhibitor N-[(2S,3R)-1-(1,3-benzodioxol-5-yl)... 3 5
Beta-secretase 1 and Cytochrome P450 3A4 inhibitor N-[(2S,3R)-... 1 0
Beta-secretase 1 and Cytochrome P450 3A4 inhibitor N-[(2S,3R)-... 15 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 10 5
Collagenase 3 inhibitor AGN-PC-03HW1J family 4 0
Peroxisome proliferator-activated receptor gamma and Peroxisom... 3 0
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 1 5
Pol polyprotein inhibitor Palinavir deriv. 13 family 1 0
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 4
Leukotriene A-4 hydrolase inhibitor SureCN3030546 family 9 1
Renin inhibitor SureCN7300793 family 2 5


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27761 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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