CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11937
Family Name C-C chemokine receptor type 3 ligand 1-(3-acetylphenyl)-3-[3-[(2R,4S)-4-[(4-fluorophenyl)methyl]-2-[(1S)-1-hydroxypentyl]piperidin-1-yl]propyl]urea family
No. of Seeds 9 No. of Other Members 1
Family Centroid CFAMM00412712 Functional Category Bioactive with Natural Product
Superfamily Alpha adrenergic receptor Ligand Droperidol Superfamily
Class Class 252

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Motilin receptor Ligand GSK962040 Family 30 457
Kappa-type opioid receptor Ligand Asimadoline Family 14 54
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
K-604 family 4 71
Pan-DAC Inhibitor AR-42 Family 21 153
Amonafide family 3 35
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Integrin alpha-2 and Integrin beta-3 Inhibitor 3-(3-(carbamoyl... 7 13
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Beta-secretase 1 Inhibitor KMI-538 Family 4 20
Beta-secretase 1 Inhibitor GSK-188909 Family 16 11
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
Cathepsin K inhibitor [(3S)-4,4-dimethyl-2-oxo-1-(phenylcarbam... 3 1
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEDE family 7 17
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZFJZ family 1 3
Beta-secretase 1 and Cathepsin D inhibitor 3-(4-chloro-N-methy... 1 0
C-C chemokine receptor type 3 ligand 4-[(3-acetylphenyl)carbam... 3 4
C-C chemokine receptor type 3 ligand SureCN6704607 family 3 22
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 4
C-C chemokine receptor type 3 ligand SureCN6703027 family 2 1
Hypoxia-inducible factor 1-alpha and Ubiquitin carboxyl-termin... 1 1
Prelamin-A/C and Lysine-specific demethylase 4E inhibitor 4-(4... 2 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 5 2
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 1
Pol polyprotein inhibitor AC1LAMTL family 11 15
Pol polyprotein inhibitor 3-[(4R,5R,6R)-4-benzyl-3-(3-carbamoy... 3 1
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
C-C chemokine receptor type 3 and Sodium-dependent serotonin t... 12 2
Delta-type opioid receptor and Potassium voltage-gated channel... 3 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
C-C chemokine receptor type 2 ligand N-[2-[[(2S,3S)-1-[(2,4-di... 13 8
Bifunctional epoxide hydrolase 2 inhibitor 1-(3-acetylphenyl)-... 1 3
ALK tyrosine kinase receptor ligand 4-fluoro-N-[6-(piperidin-1... 10 7
Cathepsin D and Cathepsin E inhibitor methyl (2S)-1-[(2R)-2-[[... 1 0
Phospholipase D1 and Phospholipase D2 inhibitor 4-bromo-N-[(2S... 1 2
Vesicular acetylcholine transporter and Sigma non-opioid intra... 5 0
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
Beta-secretase 1 inhibitor 1-N-[(1R,2S)-1-[(2R,4S)-4-butoxypip... 5 1
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
Proteinase-activated receptor 1 ligand 2-[[2-[[2-[acetyl-[(E)-... 6 15
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-037CNR f... 5 8
C-C chemokine receptor type 3 ligand AGN-PC-075BAT family 1 0
Beta-secretase 1 and Beta-secretase 2 inhibitor AC1N6ZLA family 1 0
Vascular endothelial growth factor receptor 2 ligand isoindoli... 1 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 2 0
Pol polyprotein inhibitor 3-amino-N-[(2S,3S,4R,5S)-5-[(3-amino... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZK family 3 0
Pol polyprotein inhibitor AC1LA3BI family 4 1
Integrin beta-3 and Integrin alpha-V inhibitor SureCN5878455 f... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00412709 CHEMBL49921 Bioactive 1-(3-acetylphenyl)-3-[3-[(2R,4S)-4-benzyl-2-[(1S)-1-hydroxybutyl]piperidin-1-yl]propyl]urea
CFAMM00412708 CHEMBL50233 Bioactive 1-(3-acetylphenyl)-3-[3-[(2R,4S)-4-benzyl-2-[(1S)-1-hydroxypentyl]piperidin-1-yl]propyl]urea
CFAMM00412707 CHEMBL256068 Bioactive 1-(3,5-diacetylphenyl)-3-[(2R,4R)-4-[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]-4-hydroxybutan-2-yl]urea
CFAMM00412712 CHEMBL300699 Bioactive 1-(3-acetylphenyl)-3-[3-[(2R,4S)-4-[(4-fluorophenyl)methyl]-2-[(1S)-1-hydroxypentyl]piperidin-1-yl]propyl]urea
CFAMM00412711 CHEMBL50593 Bioactive BMS compound 87b
CFAMM00412710 CHEMBL258309 Bioactive 1-(3,5-diacetylphenyl)-3-[(2S,4S)-4-[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]-4-hydroxybutan-2-yl]urea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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