CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11942
Family Name Angiopoietin-1 receptor and Vascular endothelial growth factor receptor 2 ligand SureCN1265824 family
No. of Seeds 4 No. of Other Members 8
Family Centroid CFAMM00171695 Functional Category Bioactive
Superfamily Renin and Insulin-like growth factor 1 receptor Binder Superfamily
Class Class 1070

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
DCC-2036 family 2 5
Smoothened homolog Inhibitor LDE225 Family 3 76
SB1518 family 7 103
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
MK-6096 family 3 69
JAK Inhibitor Momelotinib Family 33 83
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lyn and Tyrosine-protein kinase Lck in... 1 6
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 9 3
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
Renin inhibitor [2-(2,6-dimethylphenoxy)-6-methoxy-1-phenylpyr... 1 0
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 3 0
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Growth hormone secretagogue receptor type 1 ligand 2-methyl-6-... 2 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
ALK tyrosine kinase receptor ligand 4-fluoro-N-[1-[4-(propan-2... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 3 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
G-protein coupled bile acid receptor 1 ligand 2-ethyl-6-[3-[4-... 4 6
Motilin receptor ligand SureCN2765637 family 1 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0DB8TJ family 2 0
Angiopoietin-1 receptor ligand SureCN1939461 family 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Orexin receptor type 1 and Orexin receptor type 2 ligand (1R,2... 6 1
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Metabotropic glutamate receptor 5 and Cytochrome P450 3A4 liga... 3 7
Angiopoietin-1 receptor and Vascular endothelial growth factor... 2 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 7
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 1
Mitogen-activated protein kinase 14 inhibitor SureCN4913214 fa... 1 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Transient receptor potential cation channel subfamily V member... 2 0
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 5 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RCV family 2 1
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 19 2
Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family 2 4
Neuropeptide Y receptor type 5 ligand SureCN2658856 family 6 0
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 1 3
Tyrosine-protein kinase receptor Tie-1 and Receptor-type tyros... 1 0
Sodium channel protein type 9 subunit alpha and Potassium volt... 1 1
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-0766EI f... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00412759 CHEMBL266311 Bioactive SureCN1265259
CFAMM00412755 CHEMBL218632 Bioactive 870223-96-4

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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