CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11943
Family Name Neuromedin-K receptor and Potassium voltage-gated channel subfamily H member 2 ligand SureCN4241782 family
No. of Seeds 13 No. of Other Members 2
Family Centroid CFAMM00025911 Functional Category Bioactive
Superfamily Neuromedin-K receptor and Menin Binder Superfamily
Class Class 4870

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Saquinavir Family 64 428
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
Setipiprant family 5 118
CP-18770 family 6 27
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Urotensin-2 receptor Ligand Palosuran Family 4 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Endothelin B receptor Ligand IRL-2500 Family 34 87
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4R,... 3 7
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 13 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SVV family 2 12
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
5-hydroxytryptamine receptor 3A ligand 3-methyl-N-[7-[[3-methy... 2 0
Hematopoietic prostaglandin D synthase inhibitor 4-(3-methylis... 1 7
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Motilin receptor ligand SureCN2768052 family 3 0
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Neuromedin-K receptor ligand SureCN3894466 family 1 0
Plasmepsin-2 and Cathepsin D inhibitor N'-(3,4-dimethylacridin... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[4-[3-(dimethylamino)... 106 49
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
P2Y purinoceptor 12 inhibitor (4S)-4-[(4,6-diphenylpyridine-2-... 1 0
P2Y purinoceptor 12 inhibitor pentyl 4-[(2S)-5-[(2-methylpropa... 18 0
Neuromedin-K receptor ligand AGN-PC-00GCXP family 3 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00412772 CHEMBL220963 Bioactive SureCN4238568
CFAMM00412765 CHEMBL219330 Bioactive AGN-PC-00JCUH
CFAMM00412771 CHEMBL374307 Bioactive SureCN4237097
CFAMM00412770 CHEMBL221238 Bioactive SureCN4230184
CFAMM00412763 CHEMBL222078 Bioactive SureCN4229035
CFAMM00412769 CHEMBL221237 Bioactive SureCN4230305
CFAMM00412762 CHEMBL375638 Bioactive SureCN4235056
CFAMM00412768 CHEMBL375419 Bioactive SureCN4242954
CFAMM00412761 CHEMBL375639 Bioactive SureCN4239070
CFAMM00412774 CHEMBL221445 Bioactive methyl N-[[3-[(4-tert-butylpiperazin-1-yl)methyl]-8-fluoro-2-phenylquinoline-4-carbonyl]amino]-N-phenylcarbamate
CFAMM00412767 CHEMBL221444 Bioactive methyl N-[[3-[[1-(oxan-4-yl)piperidin-4-yl]methyl]-2-phenylquinoline-4-carbonyl]amino]-N-phenylcarbamate
CFAMM00412773 CHEMBL220803 Bioactive SureCN4229768

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27298 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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