CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11946
Family Name Rho-associated protein kinase 1 and Ribosomal protein S6 kinase alpha-1 inhibitor SureCN3883513 family
No. of Seeds 4 No. of Other Members 5
Family Centroid CFAMM00390914 Functional Category Bioactive
Superfamily Rho-associated protein kinase 2 and Nonstructural protein 1 Binder Superfamily
Class Class 1276

Cousin Family NamesSeedsMembers
Macrophage colony-stimulating factor 1 Inhibitor ABT-869 Family 8 56
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand N-(1h... 2 12
Cytochrome P450 3A4 Inhibitor 5-(2-phenethylpiperazin-1-yl)-1h... 12 35
Serine/threonine-protein kinase 17A and Myosin light chain kin... 3 7
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 18
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
cAMP-dependent protein kinase catalytic subunit PRKX and cGMP-... 1 3
Rho-associated protein kinase 2 inhibitor 2-[(3S,4R)-4-(4-fluo... 9 0
Platelet-derived growth factor receptor beta and Ribosomal pro... 1 1
Serine/threonine-protein kinase PLK4 inhibitor 4-[(E)-2-[6-[(E... 2 3
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Serine/threonine-protein kinase Chk1 inhibitor 5-[(2S)-3-amino... 4 6
Histone deacetylase 1 inhibitor N-hydroxy-N',N'-bis[2-(1H-inda... 1 0
Rho-associated protein kinase 1 and Ribosomal protein S6 kinas... 4 2
Rho-associated protein kinase 2 and Cytochrome P450 3A4 inhibi... 3 5


External ID

Functional Category

Molecule Name

CFAMM00412799 CHEMBL218720 Bioactive GSK466314A
CFAMM00412798 CHEMBL441702 Bioactive GSK270822A

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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