CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11951
Family Name Integrin beta-3 and Integrin alpha-2 inhibitor 3-(4-methoxyphenyl)-3-[[3-nitro-5-(1,2,3,4-tetrahydroisoquinolin-7-ylcarbamoyl)benzoyl]amino]propanoic acid family
No. of Seeds 4 No. of Other Members 6
Family Centroid CFAMM00412821 Functional Category Bioactive with Natural Product
Superfamily Disintegrin and Lethal factor Binder Superfamily
Class Class 1560

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Histamine H1 receptor Ligand Tranilast Family 5 125
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Potassium ... 1 15
Cruzipain Inhibitor 1-(3-methoxy-benzyl)-5-methyl-1h-indole-2,... 2 11
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Multidrug resistance protein 1 and Multidrug resistance-associ... 3 55
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 8 39
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Integrin beta-1 and Integrin alpha-4 inhibitor (3S)-3-(3,4-dim... 5 61
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Acrosin and Trypsin-1 inhibitor (4-methylphenyl) 4-(diaminomet... 10 13
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Prostaglandin D2 receptor 2 ligand SureCN136287 family 1 9
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 5
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-075FY0 f... 1 0
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Melanin-concentrating hormone receptor 1 and Potassium voltage... 3 6
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 7
C-C chemokine receptor type 5 ligand dimethyl-[[4-[[7-(4-methy... 7 8
Capsid scaffolding protein inhibitor AC1MHP1L family 3 6
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 10 1
Mitogen-activated protein kinase 14 inhibitor SureCN4822166 fa... 1 4
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
Retinoic acid receptor RXR-gamma and Retinoic acid receptor RX... 3 36
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
Cyclin-dependent kinase 4 inhibitor SureCN13343915 family 2 2
Cyclin-dependent kinase 4 inhibitor SureCN3563106 family 1 1
Histone deacetylase 1 and Histone deacetylase 2 inhibitor 4-[3... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00412820 CHEMBL218963 Bioactive AGN-PC-00S5OW
CFAMM00412819 CHEMBL376893 Bioactive AGN-PC-00S5OY
CFAMM00412824 CHEMBL385939 Bioactive 3-(3,4-dimethoxyphenyl)-3-[[3-nitro-5-(1,2,3,4-tetrahydroisoquinolin-7-ylcarbamoyl)benzoyl]amino]propanoic acid
CFAMM00412821 CHEMBL219051 Bioactive 3-(4-methoxyphenyl)-3-[[3-nitro-5-(1,2,3,4-tetrahydroisoquinolin-7-ylcarbamoyl)benzoyl]amino]propanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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