CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11962
Family Name Vascular endothelial growth factor receptor 2 and Angiopoietin-1 receptor ligand CHEMBL257788 family
No. of Seeds 14 No. of Other Members 0
Family Centroid CFAMM00169366 Functional Category Bioactive
Superfamily Mitogen-activated protein kinase 14 and Tyrosine-protein kinase Lck Inhibitor GW-788388 Superfamily
Class Class 2305

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
B-lymphocyte antigen CD20 Inhibitor Rituxan Immunology Family 10 17
Growth hormone receptor Ligand EP-51216 Family 34 390
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
NF-kappa-B and Protein kinase C zeta type Inhibitor Go6976 Family 9 71
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Cyclin-dependent kinase 1 and G2/mitotic-specific cyclin-B1 In... 2 0
Vascular endothelial growth factor receptor 2 Ligand Isoindoli... 11 36
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 5 10
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Serine/threonine-protein kinase Chk1 Inhibitor BIS-IMIDE A Family 1 3
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 19 12
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Endothelin B receptor Ligand IRL-2500 Family 34 87
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Histone deacetylase Inhibitor ST-5732 Family 8 6
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 3 1
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 2 1
Vascular endothelial growth factor receptor 2 and Angiopoietin... 4 1
Glycogen synthase kinase-3 beta inhibitor AGN-PC-07ZA4D family 1 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 4
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
Disintegrin and metalloproteinase domain-containing protein 17... 2 11
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Mitogen-activated protein kinase 14 inhibitor AGN-PC-069K8I fa... 12 3
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
Serine/threonine-protein kinase D3 and Protein kinase C delta ... 3 0
Metabotropic glutamate receptor 1 ligand GTPL6334 family 6 4
Glycogen synthase kinase-3 beta and Tyrosine-protein kinase JA... 1 0
Glucocorticoid receptor ligand N-ethyl-2-fluoro-N-[3,3,3-trifl... 16 7
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 5 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Hepatocyte growth factor receptor ligand 9-[[3-methoxypropyl(m... 17 2
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 3 5
Protein kinase C beta type and Protein kinase C delta type inh... 1 2
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 1 0
Mitogen-activated protein kinase 9 and MAP kinase-activated pr... 1 0
Glycogen synthase kinase-3 beta inhibitor 3-(2-bromoacetyl)-4-... 1 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 0
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Histamine H3 receptor ligand N-methyl-N-[(3R)-1-propan-2-ylpyr... 3 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL1935258 family 7 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 10 0
cAMP-dependent protein kinase catalytic subunit PRKX and Rho-a... 1 1
Calcitonin gene-related peptide type 1 receptor ligand 2-[(7-m... 3 0
Calcitonin gene-related peptide type 1 receptor ligand 3-[1-[4... 5 3
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
Hepatocyte growth factor receptor ligand 5-(3-methyl-1,2-thiaz... 5 2
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
Histone deacetylase 1 inhibitor N-hydroxy-5-[1-[2-[(1-methylin... 4 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 7 2
Vascular endothelial growth factor receptor 2 and Angiopoietin... 4 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 9 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 2
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Coagulation factor X inhibitor ethyl (3R,4S)-3-[(3-chloro-1H-i... 5 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 4 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Protein kinase C alpha type and Protein kinase C delta type in... 2 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Cyclin-dependent kinase 2 inhibitor SureCN6589205 family 2 2
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Angiopoietin-1 receptor and Vascular endothelial growth factor... 1 0
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R6UP family 2 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 2 0
Wee1-like protein kinase inhibitor 4-(2-chlorophenyl)-9,9-dihy... 1 0
TGF-beta receptor type-1 ligand SureCN373106 family 4 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00412889 CHEMBL258433 Bioactive CHEMBL258433

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

23964 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543