CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11974
Family Name Nitric oxide synthase, inducible inhibitor SureCN5194847 family
No. of Seeds 24 No. of Other Members 48
Family Centroid CFAMM00413071 Functional Category Bioactive with Natural Product
Superfamily Nitric oxide synthase, inducible and Acyl-CoA desaturase 1 Binder Superfamily
Class Class 850

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Avanafi... 3 16
Adenosine receptor A2a Ligand KW-6002 Family 18 195
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 21 57
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 2 3
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Endothelin-1 receptor and Endothelin B receptor ligand SureCN1... 3 16
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(1,3-ben... 6 5
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Aurora kinase A inhibitor SureCN761545 family 2 2
Dual specificity protein kinase CLK1 and Dual specificity prot... 2 14
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 5 20
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Melanin-concentrating hormone receptor 1 ligand N-[1-(1,3-benz... 2 5
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X2X ... 2 0
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(1,3-ben... 8 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17i ... 3 6
Cathepsin K and Cathepsin L1 inhibitor 2-Cyano-pyrimidine, 17a... 5 8
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 4 2
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 11 1
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 2 1
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 1 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-amin... 4 3
Mitogen-activated protein kinase 14 inhibitor SureCN4913214 fa... 1 2
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X2R ... 1 3
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 0
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
Acyl-CoA desaturase inhibitor SureCN1182546 family 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 2 10
Multidrug resistance-associated protein 1 and Cytochrome P450 ... 1 0
Orexin receptor type 1 and Orexin receptor type 2 ligand SureC... 1 3
3-carboxamide NP ZINC20411409 Family 14 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00413086 CHEMBL222362 Bioactive N-(1,3-benzodioxol-5-ylmethyl)-2-[(2R)-4-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)-1-(2-methylpropanoyl)piperazin-2-yl]acetamide
CFAMM00413029 CHEMBL376713 Bioactive N-(1,3-benzodioxol-5-ylmethyl)-2-[1-(2-imidazol-1-ylpyrimidin-4-yl)-4-(2-phenylmethoxyacetyl)piperazin-2-yl]acetamide
CFAMM00413071 CHEMBL374132 Bioactive SureCN5194847
CFAMM00413085 CHEMBL222364 Bioactive ethyl 2-[3-[2-(1,3-benzodioxol-5-ylmethylamino)-2-oxoethyl]-4-(2-imidazol-1-ylpyrimidin-4-yl)piperazin-1-yl]acetate
CFAMM00413042 CHEMBL373881 Bioactive SureCN5191419
CFAMM00413070 CHEMBL222619 Bioactive methyl 2-[2-(1,3-benzodioxol-5-ylmethylamino)-2-oxoethyl]-4-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)piperazine-1-carboxylate
CFAMM00413084 CHEMBL385325 Bioactive SureCN5192552
CFAMM00413035 CHEMBL375404 Bioactive N-(1,3-benzodioxol-5-ylmethyl)-2-[1-(2-imidazol-1-ylpyrimidin-4-yl)-4-(3-methylbutyl)piperazin-2-yl]acetamide
CFAMM00413076 CHEMBL220834 Bioactive propan-2-yl 3-[2-(1,3-benzodioxol-5-ylmethylamino)-2-oxoethyl]-4-(2-imidazol-1-ylpyrimidin-4-yl)piperazine-1-carboxylate
CFAMM00413090 CHEMBL219792 Bioactive SureCN5189704
CFAMM00413027 CHEMBL220932 Bioactive N-(1,3-benzodioxol-5-ylmethyl)-2-[4-(2-imidazol-1-ylpyrimidin-4-yl)morpholin-3-yl]acetamide
CFAMM00413041 CHEMBL223384 Bioactive 3-[2-(1,3-benzodioxol-5-ylmethylamino)-2-oxoethyl]-4-(2-imidazol-1-ylpyrimidin-4-yl)-N-methylpiperazine-1-carboxamide
CFAMM00413068 CHEMBL223792 Bioactive SureCN5191362
CFAMM00413020 CHEMBL223634 Bioactive N-(1,3-benzodioxol-5-ylmethyl)-2-[4-benzyl-1-(2-imidazol-1-ylpyrimidin-4-yl)piperazin-2-yl]acetamide
CFAMM00413083 CHEMBL385324 Bioactive methyl (3S)-3-[2-(1,3-benzodioxol-5-ylmethylamino)-2-oxoethyl]-4-(2-imidazol-1-ylpyrimidin-4-yl)piperazine-1-carboxylate
CFAMM00413089 CHEMBL220771 Bioactive N-(1,3-benzodioxol-5-ylmethyl)-2-[4-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)-1-(2-methylpropanoyl)piperazin-2-yl]acetamide
CFAMM00413040 CHEMBL223385 Bioactive phenyl 3-[2-(1,3-benzodioxol-5-ylmethylamino)-2-oxoethyl]-4-(2-imidazol-1-ylpyrimidin-4-yl)piperazine-1-carboxylate
CFAMM00413053 CHEMBL374319 Bioactive 3-[2-(1,3-benzodioxol-5-ylmethylamino)-2-oxoethyl]-4-(2-imidazol-1-ylpyrimidin-4-yl)-N-phenylpiperazine-1-carboxamide
CFAMM00413067 CHEMBL223791 Bioactive 3-[2-(1,3-benzodioxol-5-ylmethylamino)-2-oxoethyl]-N-benzyl-4-(2-imidazol-1-ylpyrimidin-4-yl)piperazine-1-carboxamide
CFAMM00413018 CHEMBL221264 Bioactive SureCN5192591
CFAMM00413082 CHEMBL290548 Bioactive SureCN231748
CFAMM00413059 CHEMBL220156 Bioactive 2-[4-(benzenesulfonyl)-1-(2-imidazol-1-ylpyrimidin-4-yl)piperazin-2-yl]-N-(1,3-benzodioxol-5-ylmethyl)acetamide
CFAMM00413081 CHEMBL411343 Bioactive SureCN5191465
CFAMM00413030 CHEMBL373623 Bioactive N-(1,3-benzodioxol-5-ylmethyl)-2-[1-(2-imidazol-1-ylpyrimidin-4-yl)-4-methylpiperazin-2-yl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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