CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1198
Family Name Pol polyprotein inhibitor N-[(2S)-1-[[(2S,3R,4S,5S)-3,4-dihydroxy-5-[[(2R)-2-(1H-indole-2-carbonylamino)-3-methylbutanoyl]amino]-1,6-diphenylhexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-1H-indole-2-carboxamide family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00320491 Functional Category Bioactive
Superfamily Bacterial outer membrane Inhibitor Daptomycin Superfamily
Class Class 647

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Indinavir Family 36 211
HIV protease Inhibitor Saquinavir Family 64 428
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
HIV-1 protease Inhibitor Atazanavir Family 16 58
Gastrin/cholecystokinin type B receptor ligand oligopeptide Ce... 35 209
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Substance-P receptor Ligand GSK424887 Family 8 184
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Growth hormone receptor Ligand EP-51216 Family 34 390
CBP-501 family 7 8
CP-18770 family 6 27
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Lethal factor Inhibitor GM6001 Family 50 435
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
Pol polyprotein inhibitor Hydroxyethylene deriv. 12 family 13 10
Renin inhibitor [(2S,4S,5S,7R)-4-amino-8-(butylamino)-5-hydrox... 3 1
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 4 53
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... 2 5
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 0
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
Pol polyprotein and Cathepsin D inhibitor N-[(1S)-1-[(2R,3S)-3... 2 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-[(2,6... 3 14
C-C chemokine receptor type 1 ligand N-[(2S,3S,5R)-5-carbamoyl... 10 4
Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 4 2
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL1935258 family 7 2
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Beta-2 adrenergic receptor ligand SureCN5346426 family 8 0
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Somatostatin receptor type 4 and Somatostatin receptor type 5 ... 3 4
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[4-[3-(dimethylamino)... 106 49
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
P2Y purinoceptor 12 inhibitor (4S)-4-[(4,6-diphenylpyridine-2-... 1 0
Heat shock protein HSP 90-alpha inhibitor CHEMBL1760611 family 19 25
Nuclear receptor ROR-gamma and Prelamin-A/C ligand CHEMBL14461... 1 18
Voltage-dependent N-type calcium channel subunit alpha-1B liga... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00320492 CHEMBL156128 Bioactive 1-[(2R)-2-[(2-acetamido-3-hydroxybutanoyl)amino]-3-(1-acetylindol-2-yl)propanoyl]-N-benzyl-N-methyl-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxamide
CFAMM00320491 CHEMBL113225 Bioactive N-[(2S)-1-[[(2S,3R,4S,5S)-3,4-dihydroxy-5-[[(2R)-2-(1H-indole-2-carbonylamino)-3-methylbutanoyl]amino]-1,6-diphenylhexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-1H-indole-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26391 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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