CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11985
Family Name Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-ylpyrimidin-4-yl)piperidin-2-yl]-N-[(4-methoxyphenyl)methyl]acetamide family
No. of Seeds 4 No. of Other Members 3
Family Centroid CFAMM00413162 Functional Category Bioactive with Natural Product
Superfamily Nitric oxide synthase, inducible and Acyl-CoA desaturase 1 Binder Superfamily
Class Class 850

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Histamine H1 receptor Ligand Mepyramine Family 5 65
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Avanafi... 3 16
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Adenosine receptor A2a Ligand KW-6002 Family 18 195
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
Smoothened homolog Inhibitor LDE225 Family 3 76
SB1518 family 7 103
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
MK-6096 family 3 69
Eluxadoline family 4 85
Renin Inhibitor Enalkiren Family 56 44
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Glucokinase Inhibitor GKA1 Family 2 67
Tyrosine kinase Inhibitor PKI166 Family 17 198
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Peptide deformylase, mitochondrial Inhibitor 8-(2,3,4-trimetho... 8 15
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Integrin beta-3 and Integrin alpha-V inhibitor methyl (3S)-3-(... 12 13
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 17 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 2 6
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Cathepsin S and Cathepsin K inhibitor AGN-PC-07YOWS family 4 6
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Aurora kinase A inhibitor SureCN761545 family 2 2
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Serine/threonine-protein kinase mTOR and RAC-alpha serine/thre... 3 3
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Dual specificity protein kinase CLK1 and Dual specificity prot... 2 14
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 8
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 4 40
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN2059024 f... 6 3
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Cannabinoid receptor 1 ligand AGN-PC-03I5TW family 3 12
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 4
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 7
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor 2-[4-[... 2 6
Toll-like receptor 7 ligand 4-amino-1-[[6-(2-pyrrolidin-1-ylet... 2 5
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 5 20
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 42 3
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 24 5
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Histamine H3 receptor ligand AGN-PC-075YXY family 1 4
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Epidermal growth factor receptor ligand SureCN4454332 family 18 5
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 2 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17i ... 3 6
Cathepsin K and Cathepsin L1 inhibitor 2-Cyano-pyrimidine, 17a... 5 8
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 4 2
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 11 1
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 0
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 2 1
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 1 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 0
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Motilin receptor ligand SureCN2765637 family 1 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Renin and Cytochrome P450 3A4 inhibitor AGN-PC-046RG9 family 8 28
Orexin receptor type 2 and Orexin receptor type 1 ligand (2R)-... 4 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 1 0
Growth hormone secretagogue receptor type 1 and Muscarinic ace... 3 9
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Mitogen-activated protein kinase 14 inhibitor SureCN4913214 fa... 1 2
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X2R ... 1 3
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 1 3
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 1
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Nociceptin receptor and Delta-type opioid receptor ligand 2-[3... 2 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RCV family 2 1
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 0
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
Acyl-CoA desaturase inhibitor SureCN1182546 family 2 5
Acyl-CoA desaturase inhibitor SureCN1182719 family 1 0
D(2) dopamine receptor ligand AGN-PC-07C1V6 family 2 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
LIM domain kinase 2 and LIM domain kinase 1 inhibitor SureCN36... 1 1
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 1 8
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[3,4-di... 2 0
Sphingosine 1-phosphate receptor 1 ligand (2S)-2-[[2-(1H-imida... 4 7
Bifunctional epoxide hydrolase 2 and Arachidonate 5-lipoxygena... 3 0
Multidrug resistance-associated protein 1 and Cytochrome P450 ... 1 0
Orexin receptor type 1 and Orexin receptor type 2 ligand SureC... 1 3
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 4 6
Tryptophan 5-hydroxylase 1 inhibitor (2S)-2-amino-3-[4-[5-[(3,... 1 3
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 1 0
3-carboxamide NP ZINC20411409 Family 14 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00413165 CHEMBL387348 Bioactive SureCN5190054
CFAMM00413164 CHEMBL220121 Bioactive SureCN5194746
CFAMM00413162 CHEMBL374681 Bioactive 2-[1-(2-imidazol-1-ylpyrimidin-4-yl)piperidin-2-yl]-N-[(4-methoxyphenyl)methyl]acetamide
CFAMM00413166 CHEMBL387349 Bioactive SureCN5192642

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

46128 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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