CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11993
Family Name Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)phenyl]methyl]-N-imidazo[1,2-a]pyridin-5-ylpiperazine-1-carboxamide family
No. of Seeds 4 No. of Other Members 2
Family Centroid CFAMM00413190 Functional Category Bioactive
Superfamily Fatty-acid amide hydrolase 1 and Cytochrome P450 3A4 Binder Superfamily
Class Class 6

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Avanafi... 3 16
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Potassium voltage-gated channel subfamily H member 2 Ligand (1... 64 70
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 2 6
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Vascular endothelial growth factor receptor 2 and Fibroblast g... 10 3
Casein kinase I isoform delta and Mitogen-activated protein ki... 3 18
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 5 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 4
Melanin-concentrating hormone receptor 1 ligand SureCN3334861 ... 1 3
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Receptor tyrosine-protein kinase erbB-2 ligand N-[3-chloro-4-(... 4 3
Cholesteryl ester transfer protein inhibitor 1-[(1S)-1-(5-chlo... 11 8
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 2 7
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17i ... 3 6
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 11 1
Fatty-acid amide hydrolase 1 inhibitor N-(2,1,3-benzothiadiazo... 1 1
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 1
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 0
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 2 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand pheny... 1 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Reverse transcriptase/RNaseH inhibitor 1-(5-chloropyridin-2-yl... 3 0
Glucagon receptor ligand SureCN2647807 family 3 7
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 2 0
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Translocator protein inhibitor AGN-PC-04X3HY family 10 1
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KJ2 family 1 0
D(2) dopamine receptor ligand AGN-PC-07C1V6 family 2 3
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 7 4
Lysosomal Pro-X carboxypeptidase inhibitor 4-[6-[(2S)-2-(5,6-d... 2 2
Bifunctional epoxide hydrolase 2 and Arachidonate 5-lipoxygena... 3 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00BHMY ... 1 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00413191 CHEMBL2203328 Bioactive 4-[[3-(4-chlorophenoxy)phenyl]methyl]-N-imidazo[1,2-b]pyridazin-3-ylpiperazine-1-carboxamide
CFAMM00413190 CHEMBL2207356 Bioactive 4-[[3-(4-chlorophenoxy)phenyl]methyl]-N-imidazo[1,2-a]pyridin-5-ylpiperazine-1-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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