| Cousin Family Names | Seeds | Members |
|---|
| Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family | 15 | 81 |
| Gamma-secretase subunit APH-1B Inhibitor E2012 Family | 3 | 67 |
| Metabotropic glutamate receptor 1 Ligand PF-1913539 Family | 130 | 817 |
| Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family | 16 | 124 |
| Adenosine receptor A2a Ligand BIIB014 Family | 26 | 92 |
| Serine/threonine-protein kinase mTOR Inhibitor INK128 Family | 2 | 15 |
| Smoothened homolog Inhibitor LDE225 Family | 3 | 76 |
| Hepatocyte growth factor receptor Ligand Amg 208 Family | 20 | 236 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 11 | 10 |
| MK-6096 family | 3 | 69 |
| 5-hydroxytryptamine receptor 1A Ligand P-MPPI Family | 33 | 81 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 7 | 37 |
| Vascular endothelial growth factor receptor 1 and Vascular end... | 4 | 44 |
| DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... | 3 | 85 |
| Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... | 3 | 34 |
| RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... | 67 | 59 |
| C-X-C chemokine receptor type 3 Ligand AMG-487 Family | 28 | 73 |
| TGF-beta receptor type-1 Ligand SB-431542 Family | 2 | 42 |
| Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... | 7 | 15 |
| 5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... | 9 | 69 |
| Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... | 53 | 320 |
| Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... | 21 | 108 |
| Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... | 4 | 4 |
| Nitric oxide synthase, inducible and Nitric oxide synthase, br... | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-1 Ligand Divapl... | 3 | 47 |
| Reverse transcriptase Inhibitor Atevirdine Family | 4 | 55 |
| Reverse transcriptase Inhibitor UK-129485 Family | 23 | 221 |
| Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... | 3 | 15 |
| Delta-type opioid receptor and Mu-type opioid receptor Ligand ... | 18 | 72 |
| Liver carboxylesterase 1 Inhibitor SM-32504 Family | 3 | 28 |
| 5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... | 1 | 6 |
| Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... | 6 | 35 |
| Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... | 1 | 11 |
| Vascular endothelial growth factor receptor 2 and Angiopoietin... | 2 | 11 |
| Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... | 1 | 0 |
| Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... | 14 | 42 |
| Hepatocyte growth factor receptor and Receptor-type tyrosine-p... | 12 | 26 |
| Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... | 4 | 3 |
| Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... | 4 | 27 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... | 39 | 10 |
| Aurora kinase A inhibitor SureCN761545 family | 2 | 2 |
| Aurora kinase A inhibitor SureCN761045 family | 2 | 0 |
| Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... | 6 | 9 |
| 5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... | 1 | 3 |
| Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... | 3 | 19 |
| Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... | 5 | 11 |
| Disintegrin and metalloproteinase domain-containing protein 17... | 4 | 1 |
| Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... | 52 | 12 |
| cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... | 3 | 8 |
| Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... | 10 | 0 |
| Neuropeptide Y receptor type 5 ligand SureCN5771669 family | 2 | 3 |
| Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... | 1 | 2 |
| Thyroid hormone receptor beta and Ferritin light chain ligand ... | 1 | 35 |
| Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... | 2 | 1 |
| D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... | 5 | 4 |
| Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... | 1 | 12 |
| Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... | 2 | 1 |
| Dihydrofolate reductase inhibitor AC1LA5HU family | 8 | 4 |
| Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... | 4 | 11 |
| Melanocortin receptor 4 ligand AGN-PC-076AML family | 3 | 24 |
| D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... | 3 | 6 |
| MAP kinase-activated protein kinase 2 and Mitogen-activated pr... | 4 | 0 |
| Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family | 3 | 13 |
| Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... | 6 | 16 |
| Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... | 2 | 2 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 2 | 2 |
| Adenosine receptor A2b and Adenosine receptor A2a ligand AGN-P... | 2 | 0 |
| Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... | 3 | 17 |
| Platelet-activating factor receptor ligand SureCN7497229 family | 4 | 2 |
| Adenosine kinase inhibitor 7-[(4aS,7aS)-6-benzyl-3,4,4a,5,7,7a... | 2 | 1 |
| Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... | 4 | 4 |
| Cytochrome P450 26A1 inhibitor AGN-PC-09MAZ3 family | 1 | 7 |
| Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... | 2 | 1 |
| MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... | 14 | 0 |
| MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... | 2 | 5 |
| MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... | 6 | 5 |
| High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... | 5 | 12 |
| Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... | 2 | 19 |
| MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... | 3 | 0 |
| Melatonin receptor type 1B ligand CHEMBL1802020 family | 2 | 7 |
| Insulin-like growth factor 1 receptor and Potassium voltage-ga... | 2 | 2 |
| Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... | 3 | 1 |
| Fatty-acid amide hydrolase 1 inhibitor 2-(1,3-dihydroisoindol-... | 2 | 3 |
| Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... | 2 | 5 |
| Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... | 2 | 7 |
| Scavenger receptor class B member 1 ligand methyl 9-[3-(4,6-di... | 2 | 10 |
| Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... | 5 | 7 |
| Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... | 3 | 0 |
| Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... | 19 | 10 |
| Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... | 12 | 13 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... | 3 | 10 |
| MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... | 3 | 0 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 8 | 2 |
| Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 1... | 1 | 0 |
| Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... | 4 | 0 |
| Insulin-like growth factor 1 receptor ligand GSK1220512A family | 20 | 15 |
| Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... | 1 | 0 |
| Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... | 8 | 4 |
| Adenosine receptor A2b ligand 2-[5-(2,6-dioxo-1,3-dipropyl-7H-... | 1 | 0 |
| Rho-associated protein kinase 1 and cAMP-dependent protein kin... | 1 | 11 |
| Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... | 8 | 6 |
| Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... | 2 | 8 |
| Dual specificity protein kinase TTK inhibitor 2-[1-[4-[[6-(cyc... | 8 | 0 |
| Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... | 7 | 3 |
| Smoothened homolog and Mitogen-activated protein kinase 14 inh... | 7 | 11 |
| Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... | 5 | 0 |
| Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... | 3 | 0 |
| RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... | 3 | 1 |
| D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... | 2 | 2 |
| Growth hormone secretagogue receptor type 1 ligand SureCN36800... | 14 | 42 |
| Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... | 1 | 0 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 3 | 0 |
| Rho-associated protein kinase 1 inhibitor SureCN4007647 family | 8 | 4 |
| ALK tyrosine kinase receptor ligand 4-fluoro-N-[1-[4-(propan-2... | 1 | 0 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 2 | 1 |
| Angiopoietin-1 receptor and Vascular endothelial growth factor... | 4 | 8 |
| Nitric oxide synthase, inducible inhibitor SureCN5194847 family | 24 | 48 |
| Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... | 4 | 3 |
| Casein kinase I isoform gamma-2 and Casein kinase I isoform de... | 5 | 2 |
| Angiopoietin-1 receptor and Vascular endothelial growth factor... | 4 | 6 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 1 | 2 |
| Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... | 11 | 1 |
| Vascular endothelial growth factor receptor 2 and Serine/threo... | 6 | 13 |
| Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... | 2 | 2 |
| Vascular endothelial growth factor receptor 2 ligand 2-aminobe... | 3 | 5 |
| Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... | 5 | 2 |
| G-protein coupled bile acid receptor 1 ligand 2-ethyl-6-[3-[4-... | 4 | 6 |
| Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... | 2 | 8 |
| Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... | 7 | 0 |
| Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... | 8 | 5 |
| Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... | 1 | 0 |
| Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... | 1 | 1 |
| Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... | 4 | 4 |
| Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... | 2 | 0 |
| G1/S-specific cyclin-E1 and Cyclin-dependent kinase 2 inhibito... | 1 | 4 |
| Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... | 12 | 2 |
| Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... | 8 | 1 |
| Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... | 2 | 1 |
| Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... | 2 | 5 |
| Vascular endothelial growth factor receptor 2 and Angiopoietin... | 3 | 3 |
| Tyrosine-protein kinase ITK/TSK and Aurora kinase B inhibitor ... | 1 | 0 |
| cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... | 6 | 8 |
| Angiopoietin-1 receptor and Vascular endothelial growth factor... | 5 | 0 |
| Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... | 3 | 0 |
| Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... | 2 | 2 |
| C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... | 5 | 9 |
| Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... | 2 | 2 |
| Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... | 2 | 2 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... | 16 | 0 |
| Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... | 6 | 0 |
| Mitogen-activated protein kinase 14 inhibitor 4-[4-(4-fluoroph... | 1 | 5 |
| Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... | 2 | 6 |
| Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... | 2 | 2 |
| Adenosine kinase inhibitor AGN-PC-0757MS family | 2 | 0 |
| Histamine H3 receptor ligand AGN-PC-075YVW family | 1 | 2 |
| RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... | 3 | 0 |
| Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... | 3 | 2 |
| Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family | 24 | 5 |
| RAF proto-oncogene serine/threonine-protein kinase inhibitor a... | 8 | 6 |
| Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... | 2 | 3 |
| Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... | 1 | 0 |
| Platelet-activating factor receptor ligand AGN-PC-00GDIY family | 1 | 1 |
| Insulin-like growth factor 1 receptor ligand SureCN311483 family | 3 | 0 |
| Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... | 1 | 2 |
| Gastrin/cholecystokinin type B receptor ligand AGN-PC-077L8M f... | 24 | 10 |
| Cholecystokinin receptor type A ligand AGN-PC-077L8J family | 22 | 2 |
| Insulin-like growth factor 1 receptor ligand SureCN310120 family | 10 | 0 |
| Insulin-like growth factor 1 receptor and Mitogen-activated pr... | 15 | 1 |
| Cell division cycle 7-related protein kinase inhibitor Pyrrolo... | 2 | 6 |
| Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... | 8 | 0 |
| Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family | 3 | 1 |
| Insulin-like growth factor 1 receptor ligand GSK2110236A family | 5 | 0 |
| Insulin-like growth factor 1 receptor ligand AGN-PC-077MU8 family | 2 | 0 |
| Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family | 7 | 0 |
| Insulin-like growth factor 1 receptor and Mitogen-activated pr... | 6 | 0 |
| Adenosine receptor A2b and Adenosine receptor A1 ligand [4-(2,... | 6 | 15 |
| Translocator protein inhibitor AGN-PC-04X3HY family | 10 | 1 |
| C-C chemokine receptor type 3 ligand SureCN6338683 family | 1 | 2 |
| Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... | 2 | 3 |
| Cholecystokinin receptor type A ligand AGN-PC-077KXF family | 2 | 0 |
| Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family | 4 | 2 |
| Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RCV family | 2 | 1 |
| Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... | 3 | 1 |
| Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... | 19 | 2 |
| Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family | 2 | 4 |
| cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... | 7 | 6 |
| Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... | 16 | 3 |
| Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-077D0D family | 3 | 0 |
| Delta-type opioid receptor and Kappa-type opioid receptor liga... | 3 | 1 |
| Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... | 1 | 0 |
| TGF-beta receptor type-1 ligand SureCN373216 family | 3 | 14 |
| C-C chemokine receptor type 8 and Potassium voltage-gated chan... | 1 | 3 |
| RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... | 15 | 1 |
| Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... | 9 | 0 |
| Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... | 1 | 0 |
| Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... | 1 | 0 |
| Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... | 2 | 0 |
| Diacylglycerol O-acyltransferase 1 inhibitor SureCN2789698 family | 2 | 8 |
| Metabotropic glutamate receptor 5 ligand AGN-PC-09QKEE family | 1 | 0 |
Statistics of CFAM Database |
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
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How to cite our database |
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C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
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Last update by |
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2014.08.29
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