CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11999
Family Name Glycogen synthase kinase-3 beta and Casein kinase I isoform gamma-2 inhibitor 2-(5-methoxy-2-quinolin-3-ylpyrimidin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00325288 Functional Category Bioactive
Superfamily Renin and Insulin-like growth factor 1 receptor Binder Superfamily
Class Class 1070

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
Adenosine receptor A2a Ligand BIIB014 Family 26 92
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
Smoothened homolog Inhibitor LDE225 Family 3 76
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
MK-6096 family 3 69
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 37
Vascular endothelial growth factor receptor 1 and Vascular end... 4 44
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 4 4
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand Divapl... 3 47
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 6
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 1 0
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Aurora kinase A inhibitor SureCN761545 family 2 2
Aurora kinase A inhibitor SureCN761045 family 2 0
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 6 9
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 3
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Neuropeptide Y receptor type 5 ligand SureCN5771669 family 2 3
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 4 0
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Adenosine receptor A2b and Adenosine receptor A2a ligand AGN-P... 2 0
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Platelet-activating factor receptor ligand SureCN7497229 family 4 2
Adenosine kinase inhibitor 7-[(4aS,7aS)-6-benzyl-3,4,4a,5,7,7a... 2 1
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
Cytochrome P450 26A1 inhibitor AGN-PC-09MAZ3 family 1 7
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 3 1
Fatty-acid amide hydrolase 1 inhibitor 2-(1,3-dihydroisoindol-... 2 3
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Scavenger receptor class B member 1 ligand methyl 9-[3-(4,6-di... 2 10
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 3 0
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 1... 1 0
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
Adenosine receptor A2b ligand 2-[5-(2,6-dioxo-1,3-dipropyl-7H-... 1 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Dual specificity protein kinase TTK inhibitor 2-[1-[4-[[6-(cyc... 8 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
ALK tyrosine kinase receptor ligand 4-fluoro-N-[1-[4-(propan-2... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 2
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 11 1
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
G-protein coupled bile acid receptor 1 ligand 2-ethyl-6-[3-[4-... 4 6
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 0
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 1
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
G1/S-specific cyclin-E1 and Cyclin-dependent kinase 2 inhibito... 1 4
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Tyrosine-protein kinase ITK/TSK and Aurora kinase B inhibitor ... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Mitogen-activated protein kinase 14 inhibitor 4-[4-(4-fluoroph... 1 5
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
Histamine H3 receptor ligand AGN-PC-075YVW family 1 2
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 3 0
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Platelet-activating factor receptor ligand AGN-PC-00GDIY family 1 1
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
Gastrin/cholecystokinin type B receptor ligand AGN-PC-077L8M f... 24 10
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Insulin-like growth factor 1 receptor ligand SureCN310120 family 10 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Cell division cycle 7-related protein kinase inhibitor Pyrrolo... 2 6
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Insulin-like growth factor 1 receptor ligand GSK2110236A family 5 0
Insulin-like growth factor 1 receptor ligand AGN-PC-077MU8 family 2 0
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Adenosine receptor A2b and Adenosine receptor A1 ligand [4-(2,... 6 15
Translocator protein inhibitor AGN-PC-04X3HY family 10 1
C-C chemokine receptor type 3 ligand SureCN6338683 family 1 2
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RCV family 2 1
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 19 2
Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family 2 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 16 3
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-077D0D family 3 0
Delta-type opioid receptor and Kappa-type opioid receptor liga... 3 1
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 1 0
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 1 3
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 0
Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Diacylglycerol O-acyltransferase 1 inhibitor SureCN2789698 family 2 8
Metabotropic glutamate receptor 5 ligand AGN-PC-09QKEE family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00413220 CHEMBL563096 Bioactive SureCN4477622

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27744 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543