CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM120
Family Name Prothrombin inhibitor SureCN5855286 family
No. of Seeds 15 No. of Other Members 8
Family Centroid CFAMM00307351 Functional Category Bioactive
Superfamily Adenosine receptor A2b Ligand CVT-7124 Superfamily
Class Class 1286

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Histamine H1 receptor Ligand Mizolastine Family 14 603
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 6 66
HER Inhibitor AC480 Family 4 67
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Translocator protein Inhibitor Emapunil Family 7 89
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Aurora kinase B and Aurora kinase A Inhibitor PF-03814735 Family 2 12
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Olprin... 2 7
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Transient receptor potential cation channel subfamily V member... 2 26
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Prothrombin inhibitor SureCN5855598 family 4 2
Prothrombin inhibitor 2-[(2S)-1-[(2R)-2-amino-3-phenylpropanoy... 3 16
Prothrombin inhibitor SureCN7371121 family 13 3
Prothrombin inhibitor SureCN5854779 family 4 9
Prothrombin inhibitor 2-[6-chloro-3-[(2,2-difluoro-2-pyridin-2... 5 0
Prothrombin inhibitor 2-[(2S)-1-[(2R)-2-amino-3-phenylpropanoy... 3 2
Prothrombin inhibitor SureCN5856722 family 3 16
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 7
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
Cathepsin K and Potassium voltage-gated channel subfamily H me... 5 1
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Tyrosine-protein kinase JAK2 inhibitor N-[2-(3-chlorophenyl)-5... 2 11
Prelamin-A/C and Lethal(3)malignant brain tumor-like protein 1... 1 1
Prothrombin and Trypsin-1 inhibitor SureCN12636557 family 9 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Insulin-like growth factor 1 receptor ligand AGN-PC-09QGLU family 3 1
Prothrombin inhibitor AGN-PC-09QKE4 family 1 0
Prothrombin inhibitor AGN-PC-09QLAK family 10 2
Insulin-like growth factor 1 receptor and Insulin receptor lig... 1 1
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Neuropeptide Y receptor type 5 ligand (5E)-5-[(4S,5S)-4-(4-flu... 18 3
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 10 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 20
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 2
Toll-like receptor 7 ligand 4-amino-1-[[6-[(2S)-2-(pyrrolidin-... 4 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 8-... 6 2
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 6 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 2 10
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
Prothrombin inhibitor 2-[3-cyano-6-(2,2-difluoro-2-pyridin-2-y... 3 0
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
P2X purinoceptor 7 inhibitor SureCN109149 family 8 1
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-[(1-... 9 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
Prothrombin inhibitor AGN-PC-073GVF family 12 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 22
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (3... 1 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00307352 CHEMBL320172 Bioactive SureCN5854721
CFAMM00307345 CHEMBL103342 Bioactive SureCN5855305
CFAMM00307358 CHEMBL103461 Bioactive AC1LCVPE
CFAMM00307351 CHEMBL102500 Bioactive SureCN5855286
CFAMM00307364 CHEMBL1201843 Bioactive 2-[3-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-2H-pyrazin-1-yl]-N-[[5-methyl-2-(1,2,4-triazol-1-yl)phenyl]methyl]acetamide
CFAMM00307344 CHEMBL322696 Bioactive 2-[3-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-2-oxopyrazin-1-yl]-N-[[2-(tetrazol-1-yl)phenyl]methyl]acetamide
CFAMM00307363 CHEMBL327265 Bioactive 2-[6-chloro-3-[[2,2-difluoro-2-(1-oxidopyridin-1-ium-2-yl)ethyl]amino]-2-oxopyrazin-1-yl]-N-[[5-chloro-2-(1,2,4-triazol-1-yl)phenyl]methyl]acetamide
CFAMM00307343 CHEMBL323583 Bioactive SureCN5856139
CFAMM00307356 CHEMBL103738 Bioactive 2-[6-chloro-3-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-2-oxopyrazin-1-yl]-N-[[2-(tetrazol-1-yl)phenyl]methyl]acetamide
CFAMM00307362 CHEMBL104951 Bioactive 2-[6-chloro-3-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-2-oxopyrazin-1-yl]-N-[[5-chloro-2-(1,2,4-triazol-1-yl)phenyl]methyl]acetamide
CFAMM00307361 CHEMBL102866 Bioactive SureCN5855468
CFAMM00307354 CHEMBL103197 Bioactive SureCN5858376
CFAMM00307347 CHEMBL102979 Bioactive 2-[6-chloro-3-[[2,2-difluoro-2-(1-oxidopyridin-1-ium-2-yl)ethyl]amino]-2-oxopyrazin-1-yl]-N-[[2-(1,2,4-triazol-1-yl)phenyl]methyl]acetamide
CFAMM00307360 CHEMBL102122 Bioactive SureCN5855753
CFAMM00307346 CHEMBL441463 Bioactive 2-[3-[[2,2-difluoro-2-(1-oxidopyridin-1-ium-2-yl)ethyl]amino]-2-oxopyrazin-1-yl]-N-[[2-(tetrazol-1-yl)phenyl]methyl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26233 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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