CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12003
Family Name Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(4-fluoro-2-methylphenyl)-6-(4-methylsulfonylpiperazin-1-yl)pyridin-3-yl]-N,2-dimethylpropanamide family
No. of Seeds 4 No. of Other Members 0
Family Centroid CFAMM00413228 Functional Category Bioactive
Superfamily Substance-P receptor and Neuromedin-K receptor Binder Superfamily
Class Class 1006

Cousin Family NamesSeedsMembers
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Class II cytokine receptor Ligand IL-10 Family 7 45
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Neuromedin-K receptor and Substance-P receptor ligand AGN-PC-0... 18 0
Substance-P receptor ligand (3R,4S)-N-[[3,5-bis(trifluoromethy... 3 7
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 7 0
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[3-(4-cyanoph... 6 6
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[3-(4-chlorop... 4 0
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 6 0
Substance-P receptor ligand Netupitant family 5 2
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Transient receptor potential cation channel subfamily V member... 57 4
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 6 0
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Transient receptor potential cation channel subfamily V member... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor Piperazine analogue, ... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00413230 CHEMBL2203704 Bioactive 2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(4-fluoro-2-methylphenyl)-6-[(3S)-3-methyl-4-methylsulfonylpiperazin-1-yl]pyridin-3-yl]-N,2-dimethylpropanamide
CFAMM00413229 CHEMBL2203709 Bioactive 2-[3,5-bis(trifluoromethyl)phenyl]-N-[6-(4,4-dioxo-1-oxa-4$l^{6}-thia-8-azaspiro[4.5]decan-8-yl)-4-(4-fluoro-2-methylphenyl)pyridin-3-yl]-N,2-dimethylpropanamide
CFAMM00413228 CHEMBL2203708 Bioactive 2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(4-fluoro-2-methylphenyl)-6-(4-methylsulfonylpiperazin-1-yl)pyridin-3-yl]-N,2-dimethylpropanamide
CFAMM00413231 CHEMBL380705 Bioactive 2-[3,5-bis(trifluoromethyl)phenyl]-N-[6-(1,1-dioxo-1,4-thiazinan-4-yl)-4-(2-methylphenyl)pyridin-3-yl]-N,2-dimethylpropanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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