CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12005
Family Name Serine/threonine-protein kinase Chk1 and Potassium voltage-gated channel subfamily H member 2 ligand 5-[[4-(methylamino)-5-(1-methylpyrazol-4-yl)pyridin-2-yl]amino]-3-[(3R)-1-methylpyrrolidin-3-yl]oxypyrazine-2-carbonitrile family
No. of Seeds 8 No. of Other Members 4
Family Centroid CFAMM00413254 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase Chk1 and Serine/threonine-protein kinase Chk2 Binder Superfamily
Class Class 1235

Cousin Family NamesSeedsMembers
Fibroblast growth factor receptor 3 Ligand BMS-582664 Family 2 23
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 5
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 3 9
Serine/threonine-protein kinase Chk1 and Potassium voltage-gat... 2 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00413254 CHEMBL2203841 Bioactive 5-[[4-(methylamino)-5-(1-methylpyrazol-4-yl)pyridin-2-yl]amino]-3-[(3R)-1-methylpyrrolidin-3-yl]oxypyrazine-2-carbonitrile
CFAMM00413247 CHEMBL2203839 Bioactive 5-[[4-(methylamino)-5-(1-methylpyrazol-4-yl)pyridin-2-yl]amino]-3-[(3R)-pyrrolidin-3-yl]oxypyrazine-2-carbonitrile
CFAMM00413253 CHEMBL2203842 Bioactive 5-[[4-(methylamino)-5-(1-methylpyrazol-4-yl)pyridin-2-yl]amino]-3-[(3S)-1-methylpyrrolidin-3-yl]oxypyrazine-2-carbonitrile
CFAMM00413252 CHEMBL2203843 Bioactive 3-[(2R)-1-(dimethylamino)propan-2-yl]oxy-5-[[4-methoxy-5-(1-methylpyrazol-4-yl)pyridin-2-yl]amino]pyrazine-2-carbonitrile
CFAMM00413245 CHEMBL2204592 Bioactive 3-[(2R)-1-(dimethylamino)propan-2-yl]oxy-5-[[4-(methylamino)-5-(1-methylpyrazol-4-yl)pyridin-2-yl]amino]pyrazine-2-carbonitrile
CFAMM00413251 CHEMBL2203844 Bioactive 5-[[4-methoxy-5-(1-methylpyrazol-4-yl)pyridin-2-yl]amino]-3-[(3R)-pyrrolidin-3-yl]oxypyrazine-2-carbonitrile
CFAMM00413250 CHEMBL2203845 Bioactive 5-[[4-methoxy-5-(1-methylpyrazol-4-yl)pyridin-2-yl]amino]-3-[(3R)-1-methylpyrrolidin-3-yl]oxypyrazine-2-carbonitrile
CFAMM00413255 CHEMBL2203840 Bioactive 5-[[4-(methylamino)-5-(1-methylpyrazol-4-yl)pyridin-2-yl]amino]-3-[(3S)-pyrrolidin-3-yl]oxypyrazine-2-carbonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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