CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12046
Family Name Angiopoietin-1 receptor and Vascular endothelial growth factor receptor 2 ligand SureCN1264649 family
No. of Seeds 4 No. of Other Members 6
Family Centroid CFAMM00171665 Functional Category Bioactive
Superfamily MK-6096 Superfamily
Class Class 1305

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
DCC-2036 family 2 5
Smoothened homolog Inhibitor LDE225 Family 3 76
SB1518 family 7 103
MK-6096 family 3 69
JAK Inhibitor Momelotinib Family 33 83
Glucokinase Inhibitor GKA1 Family 2 67
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 37
Serine/threonine-protein kinase Chk1 Inhibitor N-(5,6-diphenyl... 9 100
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Melanin-concentrating hormone receptor 1 Ligand Gnf-pf-2322 Fa... 3 95
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
Integrin beta-3 and Integrin alpha-V inhibitor methyl (3S)-3-(... 12 13
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lyn and Tyrosine-protein kinase Lck in... 1 6
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 5 25
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Mitogen-activated protein kinase 14 inhibitor AGN-PC-00HIVP fa... 2 7
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Somatostatin receptor type 5 ligand AGN-PC-088VSK family 2 3
Aurora kinase A inhibitor SureCN761545 family 2 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 22
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
B2 bradykinin receptor ligand (E)-3-[6-(2-oxopyrrolidin-1-yl)p... 3 2
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Histamine H3 receptor ligand SureCN7251693 family 3 1
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 2 3
Renin inhibitor [2-(2,6-dimethylphenoxy)-6-methoxy-1-phenylpyr... 1 0
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 3 0
Vascular endothelial growth factor receptor 1 and Receptor-typ... 2 11
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Vascular endothelial growth factor receptor 1 ligand CHEMBL197... 1 2
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Activated CDC42 kinase 1 inhibitor 6-[4-(2-morpholin-4-ylethox... 7 1
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 3 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Motilin receptor ligand SureCN2765637 family 1 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0DB8TJ family 2 0
Angiopoietin-1 receptor ligand SureCN1939461 family 1 0
Renin and Cytochrome P450 3A4 inhibitor AGN-PC-046RG9 family 8 28
Orexin receptor type 1 and Orexin receptor type 2 ligand (1R,2... 6 1
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Metabotropic glutamate receptor 5 and Cytochrome P450 3A4 liga... 3 7
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 7
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 1
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 1
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Transient receptor potential cation channel subfamily V member... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 2 2
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family 2 4
Neuropeptide Y receptor type 5 ligand SureCN2658856 family 6 0
Tyrosine-protein kinase receptor Tie-1 and Receptor-type tyros... 1 0
Serine/threonine-protein kinase Nek2 and Serine/threonine-prot... 9 4
Sodium channel protein type 9 subunit alpha and Potassium volt... 1 1
Diacylglycerol O-acyltransferase 1 inhibitor 3-[[1-[5-[(3-meth... 1 1
Diacylglycerol O-acyltransferase 1 inhibitor 2-[[4-[5-[(3-meth... 2 6
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-0766EI f... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00413512 CHEMBL245745 Bioactive 4-methyl-3-[3-[2-(methylamino)pyridin-4-yl]pyridin-2-yl]oxy-N-(3-propan-2-ylphenyl)benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27746 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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