CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12055
Family Name Peroxisome proliferator-activated receptor gamma and Peroxisome proliferator-activated receptor alpha ligand (2S)-2-[[6-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridin-3-yl]methyl]oxolane-2-carboxylic acid family
No. of Seeds 10 No. of Other Members 5
Family Centroid CFAMM00067663 Functional Category Bioactive
Superfamily Peroxisome proliferator-activated receptor alpha and Peroxisome proliferator-activated receptor gamma Binder Superfamily 3
Class Class 2976

Cousin Family NamesSeedsMembers
Cyclooxygenase Inhibitor Oxaprozin Family 33 450
Phospholipase A2, membrane associated Inhibitor Varespladib Fa... 37 190
Peroxisome proliferator-activated receptor alpha Ligand Alegli... 29 7
Substance-P receptor Ligand R 673 Family 2 127
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Fatty-acid amide hydrolase 1 Inhibitor 1-(oxazolo[4,5-b]pyridi... 19 34
Fatty-acid amide hydrolase 1 Inhibitor 1-(5-(pyridin-2-yl)oxaz... 10 142
Cytochrome P450 3A4 Inhibitor 3-(5-((methylthio)methyl)furan-2... 4 14
Prostacyclin receptor and Prostaglandin E2 receptor EP3 subtyp... 4 17
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-[5-(4-hydroxyphe... 4 36
Leukotriene A-4 hydrolase Inhibitor 2-[4-(2-azepan-1-ylethoxy)... 5 15
Peroxisome proliferator-activated receptor alpha Ligand BMS-68... 10 16
Fatty-acid amide hydrolase 1 Inhibitor 1-(5-(furan-2-yl)oxazol... 2 1
Fatty-acid amide hydrolase 1 Inhibitor 3-(benzo[d]oxazol-2-yl)... 1 6
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 7
Peroxisome proliferator-activated receptor delta ligand SureCN... 8 19
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[3-(1,3-be... 3 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 21
Phospholipase A2 inhibitor SureCN7046992 family 2 3
Phospholipase A2 inhibitor 2-[2-ethyl-1-oxamoyl-3-[(5-thiophen... 1 0
Histone deacetylase 1 and Histone deacetylase 2 inhibitor AGN-... 4 15
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Retinoic acid receptor beta and Retinoic acid receptor alpha l... 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 3
Fatty-acid amide hydrolase 1 inhibitor SureCN1471727 family 2 19
Cathepsin S and Cathepsin K inhibitor N-[(2S)-3-(1-methylcyclo... 2 0
Thromboxane-A synthase and Thromboxane A2 receptor ligand Sure... 5 37
Cytochrome P450 2C19 and Inositol monophosphatase 1 inhibitor ... 1 0
Inosine-5'-monophosphate dehydrogenase inhibitor SureCN1318237... 2 12
Glycylpeptide N-tetradecanoyltransferase 2 and Glycylpeptide N... 8 10
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 7
Histamine H3 receptor ligand SureCN2784306 family 5 3
Fatty-acid amide hydrolase 1 inhibitor methyl 6-[2-[3-(4-pheny... 8 5
Fatty-acid amide hydrolase 1 inhibitor [(2S)-6-phenoxy-1,2,3,4... 3 6
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 4 1
Fatty-acid amide hydrolase 1 and Liver carboxylesterase 1 inhi... 2 2
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[(2S,4S)-4-f... 4 7
Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 1
Sphingosine 1-phosphate receptor 1 ligand 6-[2-[6-propan-2-ylo... 1 1
Sphingosine 1-phosphate receptor 1 ligand 6-[2-[4-phenyl-3-(tr... 2 3
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 14 24
Prostaglandin E2 receptor EP4 subtype and Prostaglandin E2 rec... 7 1
Sphingosine 1-phosphate receptor 1 ligand AGN-PC-00DWQL family 2 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 3
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 3
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
Beta-secretase 1 and Cytochrome P450 3A4 inhibitor N-[(2S,3R)-... 3 7
Peroxisome proliferator-activated receptor alpha and Peroxisom... 5 2
Collagenase 3 inhibitor AGN-PC-03HW1J family 4 0
Peroxisome proliferator-activated receptor gamma and Peroxisom... 3 0
Fatty-acid amide hydrolase 1 inhibitor alpha-ketooxazole, 4jj ... 1 1
Fatty-acid amide hydrolase 1 inhibitor alpha-ketooxazole, 5a f... 2 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 5 0
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 1 5
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 1
Peroxisome proliferator-activated receptor alpha ligand 5-[4-[... 1 0
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 4
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 11 3
Mitogen-activated protein kinase 14 inhibitor 4-[4-(4-fluoroph... 1 5
Peroxisome proliferator-activated receptor gamma and Peroxisom... 7 2
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-04UH7Y family 4 1
Leukotriene A-4 hydrolase inhibitor SureCN3030546 family 9 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 3
Metabotropic glutamate receptor 5 ligand SureCN504754 family 5 4
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 2 3
Metabotropic glutamate receptor 5 ligand 3-fluoro-5-(5-pyridin... 1 0
Fatty-acid amide hydrolase 1 inhibitor 7-phenyl-1-[5-[6-(2H-te... 2 0
Reverse transcriptase/RNaseH inhibitor 3-[2-(1-benzofuran-2-yl... 1 1
Sodium channel protein type 10 subunit alpha ligand AGN-PC-09M... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00413607 CHEMBL221438 Bioactive 2-[[5-[2-[2-(3-methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]ethoxy]pyridin-2-yl]methyl]oxolane-2-carboxylic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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