CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12065
Family Name Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-5-ylmethyl)-2-[(2R)-1-(2-imidazol-1-ylpyrimidin-4-yl)pyrrolidin-2-yl]acetamide family
No. of Seeds 11 No. of Other Members 1
Family Centroid CFAMM00413658 Functional Category Bioactive
Superfamily Nitric oxide synthase, inducible and Acyl-CoA desaturase 1 Binder Superfamily
Class Class 850

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Avanafi... 3 16
Adenosine receptor A2a Ligand KW-6002 Family 18 195
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 21 57
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 2 3
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Endothelin-1 receptor and Endothelin B receptor ligand SureCN1... 3 16
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(1,3-ben... 6 5
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Cathepsin S and Cathepsin K inhibitor AGN-PC-07YOWS family 4 6
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Aurora kinase A inhibitor SureCN761545 family 2 2
Dual specificity protein kinase CLK1 and Dual specificity prot... 2 14
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 5 20
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Melanin-concentrating hormone receptor 1 ligand N-[1-(1,3-benz... 2 5
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X2X ... 2 0
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(1,3-ben... 8 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17i ... 3 6
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 4 2
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 2 1
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 1 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Glycogen synthase kinase-3 beta inhibitor 3-imidazo[1,2-a]pyri... 1 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X2R ... 1 3
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 1 3
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 0
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Histidinol dehydrogenase inhibitor (3S)-3-amino-1-(1,3-benzodi... 1 0
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Acyl-CoA desaturase inhibitor SureCN1182546 family 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 4
Multidrug resistance-associated protein 1 and Cytochrome P450 ... 1 0
Orexin receptor type 1 and Orexin receptor type 2 ligand SureC... 1 3
3-carboxamide NP ZINC20411409 Family 14 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00413651 CHEMBL221208 Bioactive (2R)-N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-(6-ethyl-2-imidazol-1-ylpyrimidin-4-yl)pyrrolidine-2-carboxamide
CFAMM00413657 CHEMBL223788 Bioactive N-(1,3-benzodioxol-5-ylmethyl)-2-[1-(6-chloro-2-imidazol-1-ylpyrimidin-4-yl)piperidin-2-yl]acetamide
CFAMM00413650 CHEMBL427062 Bioactive (2R)-N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-(2-imidazol-1-ylpyrimidin-4-yl)pyrrolidine-2-carboxamide
CFAMM00413656 CHEMBL376632 Bioactive SureCN232030
CFAMM00413649 CHEMBL220880 Bioactive N-(1,3-benzodioxol-5-ylmethyl)-2-[(2R)-1-(6-ethyl-2-imidazol-1-ylpyrimidin-4-yl)pyrrolidin-2-yl]acetamide
CFAMM00413655 CHEMBL223442 Bioactive SureCN5193063
CFAMM00413654 CHEMBL440473 Bioactive AGN-PC-03S1OG
CFAMM00413647 CHEMBL220632 Bioactive N-(1,3-benzodioxol-5-ylmethyl)-2-[(2R)-1-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)pyrrolidin-2-yl]acetamide
CFAMM00413653 CHEMBL374552 Bioactive N-(1,3-benzodioxol-5-ylmethyl)-2-[1-(6-imidazol-1-ylpyrimidin-4-yl)piperidin-2-yl]acetamide
CFAMM00413652 CHEMBL442041 Bioactive SureCN5189898
CFAMM00413658 CHEMBL376733 Bioactive N-(1,3-benzodioxol-5-ylmethyl)-2-[(2R)-1-(2-imidazol-1-ylpyrimidin-4-yl)pyrrolidin-2-yl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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