CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12077
Family Name Vascular endothelial growth factor receptor 2 and Serine/threonine-protein kinase B-raf ligand N-[3-[2-(cyclopropanecarbonylamino)imidazo[1,2-b]pyridazin-6-yl]oxyphenyl]-3-fluorobenzamide family
No. of Seeds 6 No. of Other Members 13
Family Centroid CFAMM00412417 Functional Category Bioactive
Superfamily Corticotropin-releasing factor receptor 1 Ligand GW876008 Superfamily
Class Class 1070

Cousin Family NamesSeedsMembers
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
DCC-2036 family 2 5
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Ibrutinib family 2 27
MK-6096 family 3 69
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Reverse transcriptase Inhibitor Atevirdine Family 4 55
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Vascular endothelial growth factor receptor 2 ligand SureCN405... 2 8
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Adenosine receptor A3 ligand CHEMBL1834703 family 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 3
Metabotropic glutamate receptor 5 ligand SureCN4297614 family 2 5
Vascular endothelial growth factor receptor 1 and Vascular end... 11 38
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 3 0
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YLX fa... 3 1
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 9
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
ALK tyrosine kinase receptor ligand 4-fluoro-N-[1-[4-(propan-2... 1 0
Tyrosine-protein kinase SYK inhibitor 4-[[3-[8-[(5,6-dimethoxy... 2 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 3 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Vascular endothelial growth factor receptor 2 and Platelet-der... 16 11
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Adenosine receptor A1 ligand ethyl 1-(2-chloro-2-phenylethyl)-... 5 1
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 2 0
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Vascular endothelial growth factor receptor 2 ligand SureCN428... 2 0
Tyrosine-protein kinase JAK2 inhibitor 4-[[8-(4-methoxyphenyl)... 2 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 3
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Hepatocyte growth factor receptor ligand AGN-PC-00AG7Q family 1 10
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 4
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Coagulation factor X inhibitor SureCN5641901 family 5 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Translocator protein inhibitor AGN-PC-04X3HY family 10 1
Receptor-type tyrosine-protein kinase FLT3 ligand AGN-PC-00AZN... 2 7
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Delta-type opioid receptor and Kappa-type opioid receptor liga... 3 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-07R5ZB family 4 3
Dual specificity mitogen-activated protein kinase kinase 1 inh... 2 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00413763 CHEMBL2349005 Bioactive N-[3-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)oxyphenyl]-3-fluorobenzamide
CFAMM00413749 CHEMBL2348989 Bioactive N-[6-[3-[[3-(trifluoromethyl)benzoyl]amino]phenoxy]imidazo[1,2-b]pyridazin-2-yl]oxane-4-carboxamide
CFAMM00413760 CHEMBL2349002 Bioactive N-[3-[2-(cyclopropanecarbonylamino)imidazo[1,2-b]pyridazin-6-yl]oxyphenyl]pyridine-4-carboxamide
CFAMM00413752 CHEMBL2349011 Bioactive N-[6-[3-[(3-fluorobenzoyl)amino]phenoxy]imidazo[1,2-b]pyridazin-2-yl]oxane-4-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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