| Cousin Family Names | Seeds | Members |
|---|
| 5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family | 7 | 460 |
| Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family | 32 | 639 |
| Toll-like receptor 7 Ligand Imiquimod Family | 3 | 237 |
| Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... | 8 | 98 |
| Tubulin beta chain Inhibitor Mebendazole Family | 12 | 84 |
| Histamine H1 receptor Ligand Mizolastine Family | 14 | 603 |
| Metabotropic glutamate receptor 5 Ligand ADX-48621 Family | 15 | 444 |
| C-X-C chemokine receptor type 4 Ligand AMD-070 Family | 12 | 800 |
| Farnesyltransferase beta subunit, putative Inhibitor BMS214662... | 11 | 65 |
| Transient receptor potential cation channel subfamily V member... | 15 | 457 |
| Vascular endothelial growth factor Inhibitor PTC299 Family | 6 | 145 |
| Cyclin-dependent kinase 2 Inhibitor Seliciclib Family | 29 | 292 |
| Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... | 10 | 56 |
| Fibroblast growth factor receptor 2 and Fibroblast growth fact... | 11 | 86 |
| Cannabinoid receptor 1 Ligand CP-945598 Family | 18 | 173 |
| Reverse transcriptase Inhibitor Dapivirine Family | 5 | 72 |
| 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... | 14 | 234 |
| Adenosine receptor A1 Ligand SLV320 Family | 6 | 79 |
| Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family | 53 | 580 |
| HCV NS4B protein Inhibitor Clemizole Family | 2 | 43 |
| Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... | 13 | 55 |
| JNJ-39439335 family | 5 | 11 |
| SB989 family | 17 | 91 |
| Vascular endothelial growth factor receptor 2 Ligand XL999 Family | 11 | 87 |
| PF-4217903 family | 14 | 65 |
| Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family | 9 | 29 |
| Tryptase Inhibitor Babim Family | 12 | 90 |
| D(4) dopamine receptor Ligand L-745,870 Family | 30 | 205 |
| Tyrosine kinase Inhibitor PKI166 Family | 17 | 198 |
| Interleukin-1 receptor type 1 and Mitogen-activated protein ki... | 7 | 151 |
| Histamine H3 receptor Ligand SCH79687 Family | 11 | 29 |
| Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... | 10 | 43 |
| Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... | 31 | 66 |
| Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... | 13 | 14 |
| Adenosine receptor A3 Ligand 2,6-bis(4-chlorophenyl)-9h-purine... | 4 | 12 |
| Vascular endothelial growth factor receptor 2 Ligand 6-(1h-ben... | 2 | 5 |
| Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... | 18 | 109 |
| Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... | 14 | 13 |
| Epidermal growth factor receptor Ligand PD-158780 Family | 98 | 89 |
| Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... | 3 | 18 |
| Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... | 3 | 16 |
| Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... | 6 | 19 |
| Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... | 6 | 5 |
| Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... | 19 | 165 |
| Telomerase reverse transcriptase Inhibitor HOE-33258 Family | 10 | 33 |
| Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... | 7 | 12 |
| Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... | 8 | 5 |
| Alpha-1A adrenergic receptor Ligand A-315456 Family | 7 | 17 |
| RAC-gamma serine/threonine-protein kinase and Rho-associated p... | 16 | 46 |
| Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... | 7 | 51 |
| Adenosine receptor A3 Ligand 2-(4-nitro-1h-benzo[d]imidazol-2-... | 2 | 12 |
| Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family | 112 | 67 |
| Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... | 41 | 59 |
| Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... | 8 | 11 |
| Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... | 5 | 13 |
| Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... | 6 | 10 |
| Mitogen-activated protein kinase kinase kinase 8 and Stromelys... | 6 | 53 |
| Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... | 6 | 3 |
| Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family | 4 | 1 |
| Histamine H4 receptor Ligand A-943931 Family | 14 | 11 |
| RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... | 219 | 124 |
| Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family | 5 | 6 |
| Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... | 7 | 18 |
| Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... | 2 | 15 |
| Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... | 3 | 0 |
| Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... | 5 | 16 |
| Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... | 5 | 2 |
| Type-2 angiotensin II receptor Ligand L-158809 Family | 22 | 136 |
| Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... | 6 | 55 |
| Sodium channel protein type 1 subunit alpha and Sodium channel... | 10 | 14 |
| Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... | 6 | 3 |
| Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... | 42 | 7 |
| Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... | 3 | 13 |
| Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... | 4 | 15 |
| Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... | 2 | 3 |
| Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... | 7 | 3 |
| Corticotropin-releasing factor receptor 1 ligand SureCN5395386... | 6 | 5 |
| Dihydrofolate reductase and Bifunctional dihydrofolate reducta... | 3 | 9 |
| Corticotropin-releasing factor receptor 1 ligand N-(cyclopropy... | 2 | 10 |
| Bombesin receptor subtype-3 ligand (2R)-1-[4-[2-[5-(2,2-dimeth... | 1 | 1 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 4 | 2 |
| Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... | 3 | 12 |
| Sterol O-acyltransferase 1 inhibitor 1-(2,4-difluorophenyl)-3-... | 8 | 90 |
| Macrophage colony-stimulating factor 1 receptor and Cytochrome... | 13 | 3 |
| Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... | 4 | 3 |
| Platelet-activating factor receptor ligand AGN-PC-0750SP family | 4 | 0 |
| Histamine H4 receptor ligand SureCN602132 family | 1 | 8 |
| Melanin-concentrating hormone receptor 1 and Potassium voltage... | 8 | 27 |
| Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... | 2 | 10 |
| Adenosine receptor A3 ligand 5-butyl-8-(4-methylsulfanylphenyl... | 2 | 4 |
| Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... | 7 | 10 |
| 5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... | 2 | 1 |
| Neuropeptide Y receptor type 5 ligand 8-[6-(4-fluorophenyl)-1H... | 2 | 1 |
| C-C chemokine receptor type 5 ligand SureCN1573831 family | 4 | 3 |
| Type-1B angiotensin II receptor ligand SureCN683399 family | 3 | 0 |
| Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... | 7 | 1 |
| Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14574... | 1 | 2 |
| D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... | 13 | 8 |
| Nociceptin receptor and Kappa-type opioid receptor ligand 1-[1... | 4 | 4 |
| Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... | 4 | 4 |
| Adenosine receptor A3 and Adenosine receptor A1 ligand (8R)-8-... | 4 | 0 |
| Histamine H4 receptor ligand (2Z)-5-chloro-2-[(1-methylpiperid... | 2 | 8 |
| Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... | 1 | 0 |
| Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... | 5 | 0 |
| Transient receptor potential M8 protein ligand 2-[(E)-2-(oxan-... | 5 | 3 |
| Transient receptor potential cation channel subfamily M member... | 9 | 0 |
| Transient receptor potential M8 protein and Cytochrome P450 2C... | 4 | 0 |
| Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... | 9 | 10 |
| Glycogen synthase kinase-3 beta and Dual specificity protein k... | 4 | 5 |
| Corticotropin-releasing factor receptor 1 ligand SureCN6301726... | 4 | 1 |
| Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... | 4 | 7 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 3 | 0 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 3 | 5 |
| C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... | 8 | 8 |
| Type-1 angiotensin II receptor and Peroxisome proliferator-act... | 6 | 0 |
| Sodium-dependent dopamine transporter and Sodium-dependent nor... | 2 | 3 |
| Somatostatin receptor type 5 and Somatostatin receptor type 2 ... | 6 | 3 |
| Progesterone receptor ligand AGN-PC-00B9AT family | 4 | 4 |
| Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... | 9 | 3 |
| Histamine H4 receptor and Histamine H3 receptor ligand (E)-[(3... | 4 | 3 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 2 | 0 |
| Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family | 10 | 11 |
| Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... | 3 | 1 |
| Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... | 2 | 2 |
| Protein kinase C zeta type and Cyclin-dependent kinase 2 inhib... | 2 | 13 |
| Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... | 10 | 6 |
| Platelet-derived growth factor receptor beta and Vascular endo... | 5 | 12 |
| Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... | 4 | 5 |
| Somatostatin receptor type 3 and Potassium voltage-gated chann... | 3 | 0 |
| Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... | 2 | 2 |
| Transient receptor potential cation channel subfamily V member... | 4 | 0 |
| Melanin-concentrating hormone receptor 1 ligand AGN-PC-00BSP9 ... | 6 | 12 |
| Transient receptor potential cation channel subfamily V member... | 6 | 2 |
| Fibroblast growth factor receptor 1 and Vascular endothelial g... | 5 | 0 |
| Mitogen-activated protein kinase 14 inhibitor imidazole 81 family | 2 | 1 |
| Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family | 8 | 0 |
| Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family | 16 | 1 |
| Neuropeptide Y receptor type 5 ligand 2-(3-phenylpiperidin-1-y... | 6 | 2 |
| Melanin-concentrating hormone receptor 1 ligand 3-[(1R,3R,6S)-... | 2 | 4 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 6 | 2 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 1 | 0 |
| Somatostatin receptor type 3 and Potassium voltage-gated chann... | 3 | 3 |
| Somatostatin receptor type 3 and Somatostatin receptor type 4 ... | 5 | 1 |
| Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family | 2 | 0 |
| Urokinase plasminogen activator surface receptor ligand 3-(1H-... | 4 | 0 |
| Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... | 2 | 0 |
| Melanocortin receptor 4 ligand AGN-PC-076AMO family | 17 | 8 |
| Tyrosine-protein kinase JAK1 and Aurora kinase A inhibitor CHE... | 2 | 0 |
| CGMP-dependent protein kinase inhibitor SureCN14561191 family | 4 | 0 |
| Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... | 2 | 1 |
| Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... | 2 | 0 |
| Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... | 16 | 0 |
| Melanin-concentrating hormone receptor 1 and Potassium voltage... | 4 | 4 |
| Cathepsin K inhibitor SureCN4141224 family | 3 | 0 |
| Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... | 5 | 13 |
| Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... | 6 | 2 |
| Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... | 3 | 0 |
| LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... | 4 | 0 |
| D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... | 2 | 2 |
| Neuropeptide Y receptor type 5 ligand SureCN6835211 family | 1 | 2 |
| Mitogen-activated protein kinase 14 inhibitor 6-[2-[2-chloro-6... | 2 | 0 |
| Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... | 1 | 0 |
| Diacylglycerol O-acyltransferase 1 inhibitor 2-[4-[4-[5-(6-chl... | 2 | 0 |
| Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... | 3 | 0 |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 s... | 3 | 1 |
| Type-1 angiotensin II receptor ligand SureCN7390271 family | 2 | 1 |
| Transient receptor potential cation channel subfamily V member... | 1 | 0 |
| Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... | 4 | 0 |
| Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... | 5 | 0 |
| Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... | 2 | 0 |
| Type-1 angiotensin II receptor ligand AGN-PC-04X8EF family | 1 | 1 |
| Aurora kinase B and Aurora kinase A inhibitor 1-cyclohexyl-3-[... | 4 | 0 |
| Gonadotropin-releasing hormone receptor ligand 4-[[4-[2-(4-ter... | 3 | 3 |
| Gonadotropin-releasing hormone receptor and 5-hydroxytryptamin... | 2 | 0 |
| Kappa-type opioid receptor and Mu-type opioid receptor ligand ... | 2 | 0 |
| Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... | 2 | 0 |
| D(2) dopamine receptor ligand 4-bromo-6-[2-[4-[3-(trifluoromet... | 1 | 2 |
| Gonadotropin-releasing hormone receptor ligand AGN-PC-00AWCA f... | 1 | 0 |
| Platelet-derived growth factor receptor beta and Fibroblast gr... | 10 | 0 |
| 5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family | 3 | 1 |
| 5-hydroxytryptamine receptor 2B ligand SureCN1299053 family | 1 | 1 |
| Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... | 1 | 0 |
| Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... | 14 | 0 |
| LIM domain kinase 1 and LIM domain kinase 2 inhibitor (2S)-N'-... | 9 | 0 |
| Prostaglandin E synthase inhibitor AGN-PC-04SSMB family | 6 | 0 |
| Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... | 1 | 5 |
| Reverse transcriptase/RNaseH inhibitor AC1LAPCG family | 2 | 1 |
| Acyl-CoA:cholesterol acyltransferase and Sterol O-acyltransfer... | 3 | 2 |
| Sterol O-acyltransferase 1 inhibitor AGN-PC-025JYX family | 1 | 1 |
| Small conductance calcium-activated potassium channel protein ... | 1 | 0 |
| D(2) dopamine receptor and D(4) dopamine receptor ligand 3-[1-... | 1 | 0 |
| 3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... | 1 | 1 |
Statistics of CFAM Database |
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
|
How to cite our database |
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C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
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Last update by |
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2014.08.29
|
