CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12082
Family Name Urokinase plasminogen activator surface receptor ligand 3-(1H-benzimidazol-2-yl)-1-(3-bromophenyl)-5-phenylpyrrol-2-amine family
No. of Seeds 4 No. of Other Members 0
Family Centroid CFAMM00413773 Functional Category Bioactive
Superfamily Tryptase and Adenosine receptor A1 Binder Superfamily
Class Class 667

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
HCV NS4B protein Inhibitor Clemizole Family 2 43
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Tryptase Inhibitor Babim Family 12 90
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Adenosine receptor A3 Ligand 2,6-bis(4-chlorophenyl)-9h-purine... 4 12
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Epidermal growth factor receptor Ligand N*4*-(3-bromo-phenyl)-... 7 11
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... 7 5
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Mitogen-activated protein kinase kinase kinase 8 and Stromelys... 6 53
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Reverse transcriptase Inhibitor PT-304 Family 1 0
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Platelet-activating factor receptor ligand SureCN9383514 family 4 1
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 3 5
Aurora kinase A and Aurora kinase B inhibitor 3uol family 6 5
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Adenosine receptor A3 and Adenosine receptor A1 ligand (8R)-8-... 4 0
Histamine H4 receptor ligand (2Z)-5-chloro-2-[(1-methylpiperid... 2 8
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Transient receptor potential M8 protein ligand 2-[(E)-2-(oxan-... 5 3
Transient receptor potential cation channel subfamily M member... 9 0
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 15 3
Lysosomal Pro-X carboxypeptidase inhibitor N-[(1S)-1-(5,6-dich... 3 21
Lysosomal Pro-X carboxypeptidase inhibitor 1-[(2S)-2-(5,6-dich... 2 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 3
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Protein kinase C zeta type and Cyclin-dependent kinase 2 inhib... 2 13
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 2-[8-... 2 5
Neuropeptide Y receptor type 5 and Cytochrome P450 1A2 ligand ... 8 19
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00BSP9 ... 6 12
Methionine--tRNA ligase inhibitor N-[(4R)-6,8-dibromo-1,2,3,4-... 1 1
Melanin-concentrating hormone receptor 1 ligand 3-[(1R,3R,6S)-... 6 6
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
Neuropeptide Y receptor type 5 ligand SureCN6835211 family 1 2
Mitogen-activated protein kinase 14 inhibitor 6-[2-[2-chloro-6... 2 0
Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... 1 0
Epidermal growth factor receptor ligand Pyrroloquinazoline der... 7 0
Coagulation factor X inhibitor SureCN1652469 family 2 1
Adenosine receptor A1 ligand 3-[(2-chlorophenyl)methyl]-N-cycl... 1 1
Serine/threonine-protein kinase B-raf inhibitor 1-[2-[[4-[2-cy... 2 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 1 0
Gonadotropin-releasing hormone receptor ligand 4-[[4-[2-(4-ter... 3 3
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
LIM domain kinase 1 and LIM domain kinase 2 inhibitor (2S)-N'-... 9 0
Cannabinoid receptor 1 ligand AGN-PC-07CPJ5 family 9 14
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-07... 1 1
Lysosomal Pro-X carboxypeptidase inhibitor 1-[6-[(2S)-2-(5,6-d... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00413776 CHEMBL2206698 Bioactive 3-(1H-benzimidazol-2-yl)-1-(4-bromophenyl)-5-phenylpyrrol-2-amine
CFAMM00413775 CHEMBL2206699 Bioactive 3-(1H-benzimidazol-2-yl)-1-(3-chlorophenyl)-5-phenylpyrrol-2-amine
CFAMM00413774 CHEMBL2206700 Bioactive 3-(1H-benzimidazol-2-yl)-1-(4-chlorophenyl)-5-phenylpyrrol-2-amine
CFAMM00413773 CHEMBL2206697 Bioactive 3-(1H-benzimidazol-2-yl)-1-(3-bromophenyl)-5-phenylpyrrol-2-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27264 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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