CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12084
Family Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform inhibitor N-[5-[[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-5-(morpholin-4-ylmethyl)pyridin-2-yl]amino]-2-chloropyridin-3-yl]methanesulfonamide family
No. of Seeds 7 No. of Other Members 4
Family Centroid CFAMM00413782 Functional Category Bioactive
Superfamily Adenosine kinase and Aurora kinase A Binder Superfamily
Class Class 3435

Cousin Family NamesSeedsMembers
Benzodiazepine receptor Ligand Midazolam Family 5 160
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 15 457
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 9 11
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor PF-0048... 2 13
Serine/threonine-protein kinase mTOR Inhibitor AZD2014 Family 2 41
GDC-0349 family 44 77
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 37 10
JAK Inhibitor Momelotinib Family 33 83
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A3 Ligand 2,6-bis(4-chlorophenyl)-9h-purine... 4 12
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Metabotropic glutamate receptor 5 Ligand 2-(3,5-dichlorophenyl... 2 3
Adenosine kinase inhibitor abt-702 family 14 1
Aurora kinase A inhibitor AGN-PC-07ZZEH family 2 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 6
5-hydroxytryptamine receptor 1A and D(1A) dopamine receptor li... 2 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 1
cGMP-specific 3',5'-cyclic phosphodiesterase and Potassium vol... 13 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Platelet-activating factor receptor ligand SureCN9383514 family 4 1
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 3 5
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Adenosine kinase inhibitor 5-[3-(3-bromophenyl)propyl]-6-[2-(6... 3 0
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Epidermal growth factor receptor ligand pyrido[4,3-d]pyrimidin... 11 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 8 4
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Dihydrofolate reductase inhibitor AC1LAKWV family 2 0
Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 13 1
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 1 4
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 2 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Toll-like receptor 7 ligand 4-amino-1-[[6-[(2S)-2-(pyrrolidin-... 4 0
Transient receptor potential cation channel subfamily V member... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 15 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Transient receptor potential cation channel subfamily V member... 4 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 2-[8-... 2 5
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Phosphatidylinositol 3-kinase regulatory subunit alpha and Pho... 7 13
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 0
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 18 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
Serine/threonine-protein kinase mTOR inhibitor 2-[4-[4-[(3S)-3... 3 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 4 5
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Cathepsin K inhibitor SureCN4141224 family 3 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... 1 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-03IU3J family 2 0
Adenosine kinase inhibitor SureCN8248615 family 2 3
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... 1 3
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-a]pyridine der... 4 0
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 12 0
Histamine H4 receptor ligand 2-[[6-chloro-2-(4-methylpiperazin... 7 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00413786 CHEMBL2206913 Bioactive N-[5-[[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)pyridin-2-yl]amino]-2-chloropyridin-3-yl]methanesulfonamide
CFAMM00413785 CHEMBL2206918 Bioactive N-[5-[[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-5-chloropyridin-2-yl]amino]-2-chloropyridin-3-yl]methanesulfonamide
CFAMM00413784 CHEMBL2206907 Bioactive N-[5-[[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-5-(oxan-4-yl)pyridin-2-yl]amino]-2-chloropyridin-3-yl]methanesulfonamide
CFAMM00413783 CHEMBL2206902 Bioactive N-[5-[[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-5-chloropyridin-2-yl]amino]-2-chloropyridin-3-yl]morpholine-4-sulfonamide
CFAMM00413782 CHEMBL2206908 Bioactive N-[5-[[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-5-(morpholin-4-ylmethyl)pyridin-2-yl]amino]-2-chloropyridin-3-yl]methanesulfonamide
CFAMM00413781 CHEMBL2206909 Bioactive 4-[[5-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-[[6-chloro-5-(dimethylsulfamoylamino)pyridin-3-yl]amino]pyridin-3-yl]methyl]morpholine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26197 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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