CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12094
Family Name Serine/threonine-protein kinase TBK1 and 3-phosphoinositide-dependent protein kinase 1 inhibitor N-[3-[[5-bromo-2-(3-fluoroanilino)pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide family
No. of Seeds 3 No. of Other Members 3
Family Centroid CFAMM00413854 Functional Category Bioactive
Superfamily Cruzipain and Aurora kinase B Binder Superfamily
Class Class 4886

Cousin Family NamesSeedsMembers
Transient receptor potential cation channel subfamily V member... 16 295
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Reverse transcriptase Inhibitor Dapivirine Family 5 72
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
Tyrosine-protein kinase BTK Inhibitor CC-292 Family 6 10
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
Class II cytokine receptor Ligand IL-10 Family 7 45
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 6 Inhibi... 2 3
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1
G1/S-specific cyclin-D1 and G1/S-specific cyclin-D3 inhibitor ... 6 3
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Signal transducer and activator of transcription 6 inhibitor A... 3 0
ALK tyrosine kinase receptor and Insulin receptor ligand N-[(1... 3 6
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Epidermal growth factor receptor ligand N-[3-[3-methyl-7-[4-(4... 2 1
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 3 0
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Epidermal growth factor receptor ligand N-[3-[2-(4-morpholin-4... 2 2
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-00CD7W family 5 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
Transient receptor potential cation channel subfamily V member... 3 2
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 1
Transcription factor AP-1 and Nuclear factor NF-kappa-B p105 s... 2 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00413854 CHEMBL2207181 Bioactive N-[3-[[5-bromo-2-(3-fluoroanilino)pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide
CFAMM00413853 CHEMBL2207180 Bioactive N-[3-[[5-bromo-2-(3-fluoroanilino)pyrimidin-4-yl]amino]propyl]cyclopentanecarboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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