CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12095
Family Name Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclopropyl-2-[4-(1,2,4-triazol-1-yl)anilino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00326060 Functional Category Bioactive
Superfamily Menin and Polycystin-2 Binder Superfamily
Class Class 930

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... 28 56
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor PF-0048... 2 13
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
PHA848125 family 13 138
XL-888 family 16 85
PF-4217903 family 14 65
Class II cytokine receptor Ligand IL-10 Family 7 45
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Prothrombin inhibitor 2-[(2S)-1-[(2R)-2-amino-3-phenylpropanoy... 3 16
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 18
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 5 1
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Aurora kinase A and Aurora kinase B inhibitor 3uol family 6 5
TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... 9 11
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-069K8I fa... 12 3
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(4-a... 8 11
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Coagulation factor X and Trypsin-1 inhibitor SureCN3836037 family 5 4
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3
Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... 1 1
Survival motor neuron protein inhibitor CHEMBL1583999 family 1 3
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07CBUP family 2 3
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
ALK tyrosine kinase receptor and Insulin receptor ligand N-[(1... 3 6
Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... 17 3
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 20
Casein kinase II subunit alpha inhibitor AGN-PC-0766PM family 4 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 2
Mitogen-activated protein kinase 14 inhibitor ethyl N-[4-[5-(m... 5 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Cell division cycle 7-related protein kinase and Casein kinase... 2 0
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Casein kinase II subunit alpha and Homeodomain-interacting pro... 5 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 3 0
Casein kinase II subunit alpha inhibitor 7-(cyclopropylamino)-... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 16 5
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Tyrosine-protein kinase SYK and Potassium voltage-gated channe... 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 4 2
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Serine/threonine-protein kinase TBK1 and 3-phosphoinositide-de... 3 3
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Mast/stem cell growth factor receptor Kit and Proto-oncogene t... 3 5
Proto-oncogene tyrosine-protein kinase Src and Mast/stem cell ... 4 1
Casein kinase II subunit alpha inhibitor N-[2-chloro-5-[[3-cya... 2 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 9 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-[(1-... 9 0
ALK tyrosine kinase receptor ligand 3-[1-[(3-fluorophenyl)meth... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 16 0
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Casein kinase II subunit alpha inhibitor CHEMBL401945 family 12 1
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 2
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Mitogen-activated protein kinase 8 inhibitor N-[4-[4-[2-(cyclo... 1 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 11 1
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Aurora kinase A and Aurora kinase B inhibitor N-[(3E)-3-[5-(mo... 3 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (3... 1 1
Tyrosine-protein kinase receptor TYRO3 ligand 3-amino-6-(1H-in... 2 3
P2X purinoceptor 7 inhibitor N-cyano-N'-(2-methylphenyl)-4-[2-... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543