CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM121
Family Name Thymidylate synthase inhibitor (2S)-2-[[4-[(2-methyl-4-oxo-1,6,7,8-tetrahydrocyclopenta[g]quinazolin-6-yl)-prop-2-ynylamino]benzoyl]amino]-5-oxo-5-[[(1R)-1-(2H-tetrazol-5-yl)butyl]amino]pentanoic acid family
No. of Seeds 15 No. of Other Members 107
Family Centroid CFAMM00307431 Functional Category Bioactive
Superfamily Thymidylate synthase Binder Superfamily
Class Class 1253

Cousin Family NamesSeedsMembers
Thymidylate synthase inhibitor AC1LABAB family 14 3
Thymidylate synthase inhibitor (2R)-2-[[(4S)-4-carboxy-4-[[4-[... 55 43
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 4 11
Thymidylate synthase inhibitor AC1LAB82 family 17 0
Thymidylate synthase inhibitor AC1LAB7Z family 8 3
Dihydrofolate reductase and Thymidylate synthase inhibitor 2-[... 10 5
Dihydrofolate reductase inhibitor 2-[[4-carboxy-4-[[4-[(2,4-di... 3 1
Thymidylate synthase inhibitor (2S)-2-[[(4S)-4-carboxy-4-[[(4S... 7 11
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 4 1
Folylpolyglutamate synthase, mitochondrial and Dihydrofolate r... 3 0
Dihydrofolate reductase inhibitor 2-[[4-[2-(2-amino-4-oxo-1,5,... 2 0
Thymidylate synthase inhibitor SureCN6446340 family 2 1
Cationic trypsin and Prothrombin inhibitor 2-ketobenzothiazole... 1 3
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 1 0
Beta-secretase 1 inhibitor 3-[[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00307396 CHEMBL125856 Bioactive AC1LABAK
CFAMM00307483 CHEMBL157025 Bioactive (2S)-2-[[4-[(2,7-dimethyl-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]-2-fluorobenzoyl]amino]-5-oxo-5-[[(1S)-1-(2H-tetrazol-5-yl)ethyl]amino]pentanoic acid
CFAMM00307416 CHEMBL320217 Bioactive (2S)-5-[[(1R)-3-carboxy-1-(2H-tetrazol-5-yl)propyl]amino]-2-[[4-[[(6S)-2-methyl-4-oxo-1,6,7,8-tetrahydrocyclopenta[g]quinazolin-6-yl]-prop-2-ynylamino]benzoyl]amino]-5-oxopentanoic acid
CFAMM00307415 CHEMBL292920 Bioactive (2S)-4-[1-(carboxymethyl)tetrazol-5-yl]-2-[[4-[(2-methyl-4-oxo-1,6,7,8-tetrahydrocyclopenta[g]quinazolin-6-yl)-prop-2-ynylamino]benzoyl]amino]butanoic acid
CFAMM00307381 CHEMBL299062 Bioactive (2S)-4-[1-[2-[[(1R)-1-carboxyethyl]amino]-2-oxoethyl]tetrazol-5-yl]-2-[[4-[(2-methyl-4-oxo-1,6,7,8-tetrahydrocyclopenta[g]quinazolin-6-yl)-prop-2-ynylamino]benzoyl]amino]butanoic acid
CFAMM00307461 CHEMBL412127 Bioactive (2S)-4-[1-(3-carboxypropyl)tetrazol-5-yl]-2-[[4-[(2-methyl-4-oxo-1,6,7,8-tetrahydrocyclopenta[g]quinazolin-6-yl)-prop-2-ynylamino]benzoyl]amino]butanoic acid
CFAMM00307374 CHEMBL320651 Bioactive (2S)-5-[[(1R)-3-carboxy-1-(2H-tetrazol-5-yl)propyl]amino]-2-[[4-[[(6R)-2-methyl-4-oxo-1,6,7,8-tetrahydrocyclopenta[g]quinazolin-6-yl]-prop-2-ynylamino]benzoyl]amino]-5-oxopentanoic acid
CFAMM00307427 CHEMBL160502 Bioactive (2S)-5-[[(1S)-1-carboxy-3-(2H-tetrazol-5-yl)propyl]amino]-2-[[4-[(2-methyl-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]benzoyl]amino]-5-oxopentanoic acid
CFAMM00307467 CHEMBL61300 Bioactive (2S)-5-[[(1R)-3-carboxy-1-(2H-tetrazol-5-yl)propyl]amino]-2-[[4-[(2-methyl-4-oxo-1,6,7,8-tetrahydrocyclopenta[g]quinazolin-6-yl)-prop-2-ynylamino]benzoyl]amino]-5-oxopentanoic acid
CFAMM00307446 CHEMBL157459 Bioactive (2S)-5-[[(1S)-1-carboxy-3-(2H-tetrazol-5-yl)propyl]amino]-2-[[4-[(2,7-dimethyl-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]-2-fluorobenzoyl]amino]-5-oxopentanoic acid
CFAMM00307399 CHEMBL60700 Bioactive (2S)-4-[2-(carboxymethyl)tetrazol-5-yl]-2-[[4-[(2-methyl-4-oxo-1,6,7,8-tetrahydrocyclopenta[g]quinazolin-6-yl)-prop-2-ynylamino]benzoyl]amino]butanoic acid
CFAMM00307413 CHEMBL102143 Bioactive (2S)-5-[[3-carboxy-1-(2H-tetrazol-5-yl)propyl]amino]-2-[[4-[(2-methyl-4-oxo-1,6,7,8-tetrahydrocyclopenta[g]quinazolin-6-yl)-prop-2-ynylamino]benzoyl]amino]-5-oxopentanoic acid
CFAMM00307466 CHEMBL59261 Bioactive (2S)-2-[[4-[(2-methyl-4-oxo-1,6,7,8-tetrahydrocyclopenta[g]quinazolin-6-yl)-prop-2-ynylamino]benzoyl]amino]-5-oxo-5-[[(1R)-1-(2H-tetrazol-5-yl)ethyl]amino]pentanoic acid
CFAMM00307431 CHEMBL57549 Bioactive (2S)-2-[[4-[(2-methyl-4-oxo-1,6,7,8-tetrahydrocyclopenta[g]quinazolin-6-yl)-prop-2-ynylamino]benzoyl]amino]-5-oxo-5-[[(1R)-1-(2H-tetrazol-5-yl)butyl]amino]pentanoic acid
CFAMM00307404 CHEMBL299273 Bioactive (2S)-5-[[(1S)-1-carboxy-3-[1-(carboxymethyl)tetrazol-5-yl]propyl]amino]-2-[[4-[(2-methyl-4-oxo-1,6,7,8-tetrahydrocyclopenta[g]quinazolin-6-yl)-prop-2-ynylamino]benzoyl]amino]-5-oxopentanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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