CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12118
Family Name Leukotriene A-4 hydrolase inhibitor 1-[1-[[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]methyl]piperidin-4-yl]pyrrolidin-2-one family
No. of Seeds 9 No. of Other Members 13
Family Centroid CFAMM00413927 Functional Category Bioactive
Superfamily Leukotriene A-4 hydrolase and Potassium voltage-gated channel subfamily H member 2 Binder Superfamily
Class Class 1699

Cousin Family NamesSeedsMembers
Leukotriene A-4 hydrolase Inhibitor 2-(4-piperidin-1-ylmethylp... 5 47
Aurora kinase A inhibitor SureCN208325 family 1 5
Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... 1 3
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Aromatase inhibitor 2-(2-methoxypyridin-4-yl)-4-pyridin-3-yl-1... 1 9
Cholinesterase and Acetylcholinesterase inhibitor 3-[ethyl-[3-... 2 3
Leukotriene A-4 hydrolase and Potassium voltage-gated channel ... 5 0
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-(3-c... 3 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 3
Vascular endothelial growth factor receptor 2 ligand aminothia... 1 1


External ID

Functional Category

Molecule Name

CFAMM00413941 CHEMBL2207750 Bioactive 1-[5-[[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]methyl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]ethanone
CFAMM00413925 CHEMBL2207742 Bioactive 2-[4-(2-piperidin-1-ylethyl)phenoxy]-[1,3]thiazolo[4,5-b]pyridine
CFAMM00413940 CHEMBL2207751 Bioactive N-[8-[[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]methyl]-8-azabicyclo[3.2.1]octan-3-yl]acetamide
CFAMM00413939 CHEMBL2207752 Bioactive 1-[[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]methyl]piperidine-4-carboxamide
CFAMM00413923 CHEMBL2207747 Bioactive N-[8-[2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl]-8-azabicyclo[3.2.1]octan-3-yl]acetamide
CFAMM00413922 CHEMBL2207745 Bioactive 1-[2-[2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]ethanone
CFAMM00413928 CHEMBL2207749 Bioactive 1-[2-[[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]methyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]ethanone
CFAMM00413927 CHEMBL2207748 Bioactive 1-[1-[[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]methyl]piperidin-4-yl]pyrrolidin-2-one
CFAMM00413934 CHEMBL2207730 Bioactive 2-[4-(piperidin-1-ylmethyl)phenoxy]-[1,3]thiazolo[4,5-b]pyridine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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