CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12120
Family Name Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 inhibitor (2R)-1-ethyl-N-[4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00168437 Functional Category Bioactive
Superfamily Prostaglandin G/H synthase 2 Inhibitor Rpr 200765a Superfamily
Class Class 920

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Transient receptor potential cation channel subfamily V member... 15 457
Interleukin-12 subunit alpha Inhibitor STA-5326 Family 2 51
Prostaglandin G/H synthase 2 Inhibitor Rpr 200765a Family 9 125
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Reverse transcriptase Inhibitor Dapivirine Family 5 72
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Serine/threonine-protein kinase mTOR Inhibitor AZD2014 Family 2 41
GDC-0349 family 44 77
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4
Prothrombin inhibitor SureCN5856722 family 3 16
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 2 3
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 1 7
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Platelet-activating factor receptor ligand 5-methyl-2-[4-(2-me... 1 2
Caspase-1 inhibitor (3S)-3-[[(2S)-4-[2-(5-methylbenzimidazol-1... 5 27
Epidermal growth factor receptor ligand pyrido[4,3-d]pyrimidin... 11 0
Cathepsin K and Potassium voltage-gated channel subfamily H me... 3 1
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 8 4
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 1 0
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Mitogen-activated protein kinase 10 and Transcription factor A... 4 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 6 0
Toll-like receptor 7 ligand 4-amino-1-[[6-[(2S)-2-(pyrrolidin-... 4 0
Transient receptor potential cation channel subfamily V member... 2 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Casein kinase I isoform delta and Casein kinase I isoform gamm... 1 2
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 1 0
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Transient receptor potential cation channel subfamily V member... 4 0
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
Tyrosine-protein kinase JAK1 and Non-receptor tyrosine-protein... 7 0
Smoothened homolog inhibitor N-[4-methyl-3-(5-phenyl-1H-imidaz... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 0
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
Fatty-acid amide hydrolase 1 inhibitor 4-(3-phenyl-1,2,4-thiad... 2 1
Serine/threonine-protein kinase mTOR inhibitor 2-[4-[4-[(3S)-3... 3 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 1 2
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
C-C chemokine receptor type 5 ligand N-[3-[4-[3-cyclohexyl-5-(... 5 4
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 1 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 3 0
Aurora kinase B and Aurora kinase A inhibitor 1-cyclohexyl-3-[... 4 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Serine/threonine-protein kinase B-raf inhibitor imidazole-base... 2 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Transient receptor potential cation channel subfamily V member... 3 2
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 12 0
C-X-C chemokine receptor type 2 ligand (2S)-2-[[6-butyl-2-(4-m... 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26236 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543