CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12127
Family Name Mu-type opioid receptor and Delta-type opioid receptor ligand AGN-PC-0739B9 family
No. of Seeds 15 No. of Other Members 4
Family Centroid CFAMM00413979 Functional Category Bioactive
Superfamily Mu-type opioid receptor and Delta-type opioid receptor Binder Superfamily
Class Class 1664

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Endothelin-1 receptor Ligand Atrasentan Family 127 336
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 23
Microsomal triglyceride transfer protein large subunit Inhibit... 3 103
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 4
Histamine H3 receptor Ligand A-349821 Family 49 228
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Caspase-3 Inhibitor 2-(4-methoxy-benzyl)isoquinoline-1,3,4-tri... 2 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 33
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 2
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
D(2) dopamine receptor Ligand Epidepride Family 31 66
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Peroxisome proliferator-activated receptor delta and Peroxisom... 20 8
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 4 7
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 2 3
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand N-... 1 2
Disintegrin and metalloproteinase domain-containing protein 17... 28 10
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745OX family 2 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Leukotriene B4 receptor 1 ligand AGN-PC-00GEAR family 2 2
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(3-methoxy-2-methylph... 4 4
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Substance-P receptor ligand AGN-PC-075NSQ family 9 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Mu-type opioid receptor ligand 3-[(3R,4R)-1-[(2,4-dimethoxyphe... 2 4
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1589265 family 1 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Pol polyprotein inhibitor CHEMBL305466 family 4 7
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 11 6
Pol polyprotein inhibitor KNI-1279 family 3 0
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
Mu-type opioid receptor ligand AGN-PC-075GAW family 2 1
B1 bradykinin receptor ligand 4-(5-chloro-4-oxochromen-3-yl)-N... 1 5
Pol polyprotein inhibitor MDL 74538 family 11 1
Growth hormone secretagogue receptor type 1 ligand 2-[(2S)-1-[... 2 0
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 1 3
Histamine H3 receptor ligand 4-[[2-[2-[(2R)-2-methylpyrrolidin... 1 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
5-hydroxytryptamine receptor 1A ligand (3S)-3-[4-(7,9-dioxo-8-... 2 0
Delta-type opioid receptor ligand N-[(7S)-5-(3-hydroxyphenyl)-... 9 3
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-[cyano-(2-meth... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 6 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Sodium-dependent noradrenaline transporter and Sodium-dependen... 6 6
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Estrogen receptor and Estrogen receptor beta ligand SureCN1450... 1 1
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 1
Cannabinoid receptor 1 ligand AGN-PC-03RV6L family 10 3
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
Sigma non-opioid intracellular receptor 1 and D(3) dopamine re... 26 8
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Melanin-concentrating hormone receptor 1 ligand N-methyl-N-[(3... 2 2
Beta-secretase 1 inhibitor 1-N-[(2S,3R)-1-(3,5-difluorophenyl)... 8 7
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-04X9O... 2 1
Free fatty acid receptor 1 ligand (3R,4R)-3-[4-(3,4-dimethylph... 4 4
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 3 4
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 3 1
Motilin receptor and Growth hormone secretagogue receptor type... 1 2
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
Renin inhibitor N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy... 5 1
C-C chemokine receptor type 3 and Probable C-C chemokine recep... 5 2
C-C chemokine receptor type 3 ligand N-[(3R)-1-[(6-fluoronapht... 1 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
D(3) dopamine receptor ligand S33084 family 1 1
Neuromedin-K receptor ligand SureCN2478117 family 1 0
Sodium/hydrogen exchanger 1 inhibitor 4-(1-acetylpiperidin-4-y... 1 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 2-ben... 1 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00413982 CHEMBL2208359 Bioactive CHEMBL2208359
CFAMM00413988 CHEMBL249985 Bioactive SureCN12306957
CFAMM00413977 CHEMBL2208350 Bioactive CHEMBL2208350
CFAMM00413976 CHEMBL2208353 Bioactive CHEMBL2208353
CFAMM00413986 CHEMBL2208360 Bioactive CHEMBL2208360
CFAMM00413975 CHEMBL2208352 Bioactive CHEMBL2208352
CFAMM00413981 CHEMBL2208358 Bioactive CHEMBL2208358
CFAMM00413985 CHEMBL2208361 Bioactive CHEMBL2208361
CFAMM00413974 CHEMBL2208346 Bioactive CHEMBL2208346
CFAMM00413980 CHEMBL2208354 Bioactive CHEMBL2208354
CFAMM00413984 CHEMBL2208362 Bioactive CHEMBL2208362
CFAMM00413973 CHEMBL2208345 Bioactive CHEMBL2208345
CFAMM00413979 CHEMBL2208356 Bioactive AGN-PC-0739B9
CFAMM00413983 CHEMBL2208363 Bioactive CHEMBL2208363
CFAMM00413978 CHEMBL2208351 Bioactive CHEMBL2208351

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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