CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12136
Family Name Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureCN232750 family
No. of Seeds 6 No. of Other Members 0
Family Centroid CFAMM00139989 Functional Category Bioactive
Superfamily Corticosteroid 11-beta-dehydrogenase isozyme 1 and Lethal factor Binder Superfamily
Class Class 960

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Transient receptor potential cation channel subfamily V member... 16 295
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
JAK Inhibitor Momelotinib Family 33 83
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Dipeptidyl peptidase 4 Inhibitor Nvp-dpp728 Family 11 42
XL-888 family 16 85
Class II cytokine receptor Ligand IL-10 Family 7 45
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Neuromedin-K receptor and Substance-P receptor ligand AGN-PC-0... 18 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 0
Integrin beta-3 and Integrin alpha-V inhibitor SureCN3888804 f... 11 13
Substance-P receptor ligand (3R,4S)-N-[[3,5-bis(trifluoromethy... 3 7
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 1 8
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Prothrombin and Cationic trypsin inhibitor tert-butyl N-[(2R)-... 4 3
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
C-C chemokine receptor type 5 ligand AC1LA25C family 3 6
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-[[2-[6-m... 13 12
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 1
Integrin beta-3 and Integrin alpha-V inhibitor SureCN6359092 f... 9 5
Dipeptidyl peptidase 4 inhibitor SureCN3389584 family 2 2
C-C chemokine receptor type 2 and C-C chemokine receptor type ... 5 20
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 1
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 1 0
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 6 0
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-isoquinolin-1-y... 3 2
Substance-P receptor ligand Netupitant family 5 2
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Smoothened homolog inhibitor 3-pyridin-3-yl-N-[1-[[6-[4-[(3-py... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Transient receptor potential cation channel subfamily V member... 57 4
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 7 6
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 4 0
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-(6-pyrrolid... 3 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor N-(5-... 4 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticoster... 2 0
Calcitonin gene-related peptide type 1 receptor ligand (2R)-5-... 1 0
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 7 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 1
Prothrombin inhibitor N-[(6-amino-2-methylpyridin-3-yl)methyl]... 2 0
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
Transient receptor potential cation channel subfamily V member... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor Piperazine analogue, ... 4 0
Cannabinoid receptor 2 ligand AGN-PC-07CRHA family 4 8
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[(2... 3 1
Integrin beta-3 and Integrin alpha-IIb inhibitor (3S)-3-[[2-[(... 3 1
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Metabotropic glutamate receptor 1 ligand [(3aS,6aR)-2-(6-fluor... 1 0
Stromelysin-1 and Interstitial collagenase inhibitor 1-[(2S)-1... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00414017 CHEMBL222618 Bioactive SureCN234510
CFAMM00414019 CHEMBL222511 Bioactive AGN-PC-00BCEW
CFAMM00414018 CHEMBL222670 Bioactive 4-[[2-methyl-2-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]propanoyl]amino]adamantane-1-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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