CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12140
Family Name Serine/threonine-protein kinase Chk1 and Cyclin-dependent kinase 7 inhibitor 3-(Indol-2-yl)indazole 16 family
No. of Seeds 2 No. of Other Members 6
Family Centroid CFAMM00268318 Functional Category Bioactive
Superfamily Tyrosine-protein kinase ITK/TSK and Aurora kinase A Binder Superfamily
Class Class 3190

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
PF-4217903 family 14 65
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 5 10
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(1h-1,2,3-triazol-5-... 3 12
Cytochrome P450 3A4 Inhibitor 5-(2-phenethylpiperazin-1-yl)-1h... 12 35
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 14 4
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 7
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 6
Acetylcholinesterase and Cholinesterase inhibitor 3,8-DIAMINO-... 2 3
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14574... 1 2
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Tyrosine-protein kinase ITK/TSK inhibitor (3Z)-3-(6-methylindo... 2 40
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00AP1L ... 14 7
Metabotropic glutamate receptor 5 ligand AGN-PC-075GBZ family 2 5
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
Cell division cycle 7-related protein kinase and Casein kinase... 2 0
Protein kinase C zeta type and Cyclin-dependent kinase 2 inhib... 2 13
3-phosphoinositide-dependent protein kinase 1 and MAP kinase-a... 1 5
Hepatocyte growth factor receptor ligand 5-(3-methyl-1,2-thiaz... 5 2
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase Chk1 inhibitor 3-(Indol-2-yl)i... 1 1
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 1
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Casein kinase I isoform delta and Casein kinase I isoform epsi... 1 0
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 16 0
Serine/threonine-protein kinase Chk1 inhibitor 5-[7-(2-morphol... 2 2
Alpha-1A adrenergic receptor and Alpha-2A adrenergic receptor ... 3 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 10 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 6 4
Transient receptor potential cation channel subfamily V member... 1 0
TGF-beta receptor type-1 ligand N-(3-cyanophenyl)-2-[3-(6-meth... 4 5
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 7
TGF-beta receptor type-1 ligand 6-bromo-4-(2-(6-methylpyridin-... 1 3
TGF-beta receptor type-1 ligand SureCN373106 family 4 1


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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