CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12150
Family Name Bifunctional dihydrofolate reductase-thymidylate synthase inhibitor SureCN4846178 family
No. of Seeds 3 No. of Other Members 5
Family Centroid CFAMM00414110 Functional Category Bioactive with Natural Product
Superfamily Epidermal growth factor receptor and Receptor tyrosine-protein kinase erbB-2 Binder Superfamily
Class Class 2955

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Melanin-concentrating hormone receptor 1 Ligand 8-sec-butoxy-q... 30 39
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 5 45
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Dual specificity protein kinase CLK1 and Dual specificity prot... 2 14
Methionine--tRNA ligase inhibitor SureCN7818675 family 7 14
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Fatty-acid amide hydrolase 1 inhibitor (1R)-2-[[6-(3-chloro-4-... 1 4
Dihydrofolate reductase inhibitor 7-(3,4-dimethoxyphenyl)-6-me... 1 3
Dihydrofolate reductase inhibitor 7-(5-chloro-2-ethoxyphenyl)-... 2 1
Dihydrofolate reductase inhibitor 7-(2-ethoxynaphthalen-1-yl)-... 3 2
Dipeptidyl peptidase 4 inhibitor AGN-PC-075FF2 family 2 1
Vascular endothelial growth factor receptor 2 and Serine/threo... 1 2
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 1 0
Transient receptor potential cation channel subfamily V member... 2 4
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-amin... 4 3
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase and cAMP-specific... 1 3
1-acyl-sn-glycerol-3-phosphate acyltransferase beta inhibitor ... 1 2
1-acyl-sn-glycerol-3-phosphate acyltransferase beta inhibitor ... 1 1
1-acyl-sn-glycerol-3-phosphate acyltransferase beta inhibitor ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00414114 CHEMBL22129 Bioactive 5-[4-[(2,4-dichlorophenyl)methoxy]-3-methoxyphenyl]-6-ethylpyrimidine-2,4-diamine
CFAMM00414110 CHEMBL22403 Bioactive SureCN4846178
CFAMM00414108 CHEMBL278813 Bioactive SureCN4847876

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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