CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12151
Family Name Protein kinase C alpha type inhibitor [2-(hydroxymethyl)-5-oxo-4-propan-2-ylideneoxolan-2-yl]methyl 4-[2-[4-[2-(4-methoxyphenyl)ethynyl]phenyl]ethynyl]benzoate family
No. of Seeds 2 No. of Other Members 4
Family Centroid CFAMM00414121 Functional Category Bioactive
Superfamily Protein kinase C alpha type and Protein kinase C beta type Binder Superfamily
Class Class 863

Cousin Family NamesSeedsMembers
Retinoic acid receptor Ligand naphthoic acid derivative Adapal... 2 264
Histamine H1 receptor Ligand Doxepin Family 8 89
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor Mycophenola... 4 353
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Ipriflavone family 62 2480
Rotenone family 16 107
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family 7 148
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Integrase Inhibitor L-708,906 Family 1 8
Endothelin-1 receptor Ligand PD156707 Family 41 211
Estrogen receptor beta Ligand 2-(4-hydroxy-phenyl)benzofuran-5... 5 82
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 Ligand... 4 26
Aromatase and DNA-dependent protein kinase catalytic subunit I... 6 19
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Protein kinase C delta type and Protein kinase C alpha type In... 4 105
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Neutrophil elastase Inhibitor E-6-o-p-methoxycinnamoyl Scandos... 2 68
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Acetylcholinesterase Inhibitor 4-formylphenyl-o-beta-d-ribopyr... 2 17
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Retinoic acid receptor RXR-alpha and Peroxisome proliferator-a... 3 17
Cellular tumor antigen p53 and Thyrotropin receptor ligand CHE... 1 19
Eukaryotic initiation factor 4A-I inhibitor methyl (1R,2R,3S,3... 12 1
Protein kinase C delta type and Protein kinase C beta type inh... 3 9
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 8
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 7 13
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 7
Androgen receptor and Estrogen receptor ligand estradiol benzo... 1 29
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Protein kinase C delta type and Protein kinase C alpha type in... 1 10
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 7
Protein kinase C alpha type inhibitor [(1R)-4-dodecoxy-1-(hydr... 1 18
Arachidonate 5-lipoxygenase inhibitor AGN-PC-00OPWJ family 1 1
Prenol Lipids Metabolite Austalide A Family 5 4
Prenol Lipids Metabolite 13-Hydroxydihydromelleolide Family 3 0
Benzoic Acid and Derivatives Metabolite Methyl 3-(2,3-dihydrox... 1 3
Putative NP ZINC31158464 Family 3 5
NP 6-(4-ethoxyphenyl)-1,3-dimethyl-4-oxo-4h-cyclohepta[c]furan... 13 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00414117 CHEMBL471137 Bioactive [(4E)-2-(hydroxymethyl)-4-[(4-methoxyphenyl)methylidene]-5-oxooxolan-2-yl]methyl 2,4,6-tri(propan-2-yl)benzoate
CFAMM00414121 CHEMBL221332 Bioactive [2-(hydroxymethyl)-5-oxo-4-propan-2-ylideneoxolan-2-yl]methyl 4-[2-[4-[2-(4-methoxyphenyl)ethynyl]phenyl]ethynyl]benzoate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48716 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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