CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12159
Family Name Adenosine receptor A2a and Adenosine receptor A1 ligand 5-[(7S,9aS)-7-(pyridin-3-yloxymethyl)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl]-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine family
No. of Seeds 6 No. of Other Members 1
Family Centroid CFAMM00414165 Functional Category Bioactive
Superfamily Metabotropic glutamate receptor 1 Ligand PF-1913539 Superfamily
Class Class 1038

Cousin Family NamesSeedsMembers
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
Adenosine receptor A2a Ligand BIIB014 Family 26 92
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Adenosine receptor A1 and Adenosine receptor A2a Ligand CGS-15... 24 47
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 4 32
Adenosine receptor A1 and Adenosine receptor A2a Ligand ZM-241... 2 5
Mitogen-activated protein kinase 14 Inhibitor CP-808844 Family 39 43
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 1 0
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 11 0
Adenosine receptor A2a ligand SureCN6867940 family 13 13
5-hydroxytryptamine receptor 6 ligand F1609-0206 family 2 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 10 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 31 11
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 4 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 8 0
Prelamin-A/C and Prothrombin inhibitor (3-Furan-2-yl-5-methyls... 2 1
Adenosine receptor A3 and Adenosine receptor A2b ligand CHEMBL... 5 0
Survival motor neuron protein and Neuropeptide S receptor liga... 1 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 7 4
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 5 8
Adenosine receptor A2a ligand 5-N-[[(2R)-1-[(2-chloro-3,6-difl... 7 9
Adenosine receptor A2a ligand 5-[[[(2R)-1-[(2-chloropyridin-4-... 5 0
Adenosine receptor A2a ligand 2-(furan-2-yl)-7-[3-[(4-phenylpi... 11 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 7 6
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
Adenosine receptor A2a ligand 7-(3,4-dimethoxyphenyl)-2-(furan... 6 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 5
Adenosine receptor A3 ligand CHEMBL1834703 family 2 1
Vascular endothelial growth factor receptor 1 and Vascular end... 11 38
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Histamine H3 receptor ligand 2-(4-piperidin-1-ylpiperidin-1-yl... 1 3
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 1 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
Tyrosine-protein kinase SYK inhibitor 4-[[3-[8-[(5,6-dimethoxy... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 6
Vascular endothelial growth factor receptor 2 and Platelet-der... 16 11
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 0
Adenosine receptor A2a ligand 5-[(7S,9aS)-7-[(2-fluorophenoxy)... 5 4
P2X purinoceptor 7 inhibitor SureCN110566 family 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 3
Adenosine receptor A2a ligand 3-[(2-bromophenyl)methyl]-8-(fur... 2 0
Adenosine receptor A2a ligand 8-(furan-2-yl)-3-[2-[4-(1,3-thia... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 25 5
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 29 1
Adenosine receptor A2a and Adenosine receptor A1 ligand 1-[(2-... 2 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Adenosine receptor A2a ligand SureCN8368237 family 1 0
Adenosine receptor A2a ligand AGN-PC-02Z2S3 family 3 0
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 2 2
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1
Adenosine receptor A2a and Adenosine receptor A1 ligand triazi... 3 0
Aurora kinase B and Aurora kinase A inhibitor N-(furan-2-ylmet... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00414168 CHEMBL373941 Bioactive 5-[(7R,9aS)-7-[[bis(pyridin-2-ylmethyl)amino]methyl]-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl]-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine
CFAMM00414167 CHEMBL222590 Bioactive 5-[(7S,9aS)-7-(isoquinolin-5-yloxymethyl)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl]-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine
CFAMM00414166 CHEMBL222530 Bioactive 5-[(7R,9aS)-7-(quinolin-2-yloxymethyl)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl]-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine
CFAMM00414165 CHEMBL222784 Bioactive 5-[(7S,9aS)-7-(pyridin-3-yloxymethyl)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl]-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine
CFAMM00414164 CHEMBL221573 Bioactive 5-[(7R,9aS)-7-[[bis(pyridin-4-ylmethyl)amino]methyl]-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl]-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine
CFAMM00414170 CHEMBL374881 Bioactive 5-[(7S,9aS)-7-(quinolin-6-yloxymethyl)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl]-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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